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Review
. 2020 Jan;59(1):23-29.
doi: 10.1111/ijd.14684. Epub 2019 Oct 11.

The role of bioidentical hormone replacement therapy in anti-aging medicine: a review of the literature

Amanda Rosenthal  1   2 , Ted Jacoby  2 , Rachel Israilevich  2 , Ronald Moy  2
Affiliations
Review

The role of bioidentical hormone replacement therapy in anti-aging medicine: a review of the literature

Amanda Rosenthal et al. Int J Dermatol. 2020 Jan.

Erratum in

  • Corrigendum.
    [No authors listed] [No authors listed] Int J Dermatol. 2024 May;63(5):692. doi: 10.1111/ijd.16850. Epub 2023 Nov 14. Int J Dermatol. 2024. PMID: 37964425 No abstract available.

Abstract

The changes in skin and overall appearance that occur with increasing age can be partly attributed to declining hormone levels. While hormonal deficiencies are most commonly associated with postmenopausal females, males are also subject to age-related testosterone decline and may benefit from replacement of deficient hormones. However, great disparities exist between the recommendations of scientific societies and actual use of hormone supplements in aging patients. The purpose of this literature review is to discuss the role of hormones in the aging process of the skin, explain the safety profile of hormone replacement therapy, specifically discussing the superiority of bioidentical hormones, and highlight the benefits of hormone replacement in anti-aging of the skin. In summary, this literature review suggests that hormone replacement with bioidentical hormones is a safe and effective way to prevent skin aging.

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References

    1. Lephart ED. Skin aging and oxidative stress: equol's anti-aging effects via biochemical and molecular mechanisms. Ageing Res Rev 2016; 2016: 36-54.
    1. Lephart ED. A review of the role of estrogen in dermal aging and facial attractiveness in women. J Cosmet Dermatol 2018; 17: 282-288.
    1. Quan C, Cho MK, Perry D, et al. Age-associated reduction of cell spreading induces mitochondrial DNA common deletion by oxidative stress in human skin dermal fibroblasts: implication for human skin connective tissue aging. J Biomed Sci 2015; 22: 62.
    1. Qin Z, Voorhees JJ, Fisher GJ, et al. Age-associated reduction of cellular spreading/mechanical force up-regulates matrix metalloproteinase-1 expression and collagen fibril fragmentation via c-Jun/AP-1 in human dermal fibroblasts. Aging Cell 2014; 13: 1028-1037.
    1. Farage MA, Miller KW, Elsner P, et al. Structural characteristics of the aging skin: a review. Cutan Ocul Toxicol 2007; 26: 343-357.

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