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Randomized Controlled Trial
. 2020 Dec:226:52-60.
doi: 10.1016/j.schres.2019.08.033. Epub 2019 Oct 9.

Supplementation with the omega-3 long chain polyunsaturated fatty acids: Changes in the concentrations of omega-3 index, fatty acids and molecular phospholipids of people at ultra high risk of developing psychosis

Ayedh Alqarni  1 , Todd W Mitchell  2 , Patrick D McGorry  3 , Barnaby Nelson  3 , Connie Markulev  3 , Hok Pan Yuen  3 , Miriam R Schäfer  3 , Maximus Berger  3 , Nilufar Mossaheb  4 , Monika Schlögelhofer  4 , Stephan Smesny  5 , Ian B Hickie  6 , Gregor E Berger  7 , Eric Y H Chen  8 , Lieuwe de Haan  9 , Dorien H Nieman  9 , Merete Nordentoft  10 , Anita Riecher-Rössler  11 , Swapna Verma  12 , Andrew Thompson  13 , Alison Ruth Yung  14 , Barbara J Meyer  2 , G Paul Amminger  15
Affiliations
Randomized Controlled Trial

Supplementation with the omega-3 long chain polyunsaturated fatty acids: Changes in the concentrations of omega-3 index, fatty acids and molecular phospholipids of people at ultra high risk of developing psychosis

Ayedh Alqarni et al. Schizophr Res. 2020 Dec.

Abstract

Omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA) are necessary for optimum mental health, with recent studies showing low n-3 LCPUFA in people at ultra-high risk (UHR) of developing psychosis. Furthermore, people at UHR of psychosis had increased erythrocyte sphingomyelin (SM) and reduced phosphatidylethanolamine (PE) concentrations as well as 27 erythrocyte phospholipid species that differed when compared to erythrocytes from age matched people not at UHR of psychosis. The aim of this analysis was to evaluate the effect of n-3 supplementation on the different erythrocyte lipid species (including SM and PE concentrations) in people at UHR of psychosis. Participants were randomly assigned to fish oil (containing 840 mg EPA and 560 mg DHA per day) or placebo (paraffin oil) for 6 months. Fasted blood samples were taken at baseline and post intervention. Mass spectrometry was used to analyse the molecular phospholipids and fatty acid composition of erythrocytes for both groups. The n-3 index was significantly increased from 3.0% to 4.12% after 6 months of receiving n-3 capsules. Fish oil capsules increased the phospholipid molecular species containing n-3 LCPUFA, and concomitant decreases in n-6 LCPUFA species. SM species did not show any significant changes in n-3 LCPUFA group however, three SM species (SM 16:0, SM 18:0, SM 18:1) significantly increased after 6 months of supplementation with placebo. N-3 supplementation for 6 months led to higher n-3 incorporation into erythrocytes, at the expense of n-6 PUFA across all phospholipid classes analyzed and may have prevented the increase in SM seen in the placebo group.

Keywords: Fatty acids; Omega-3 index; Phospholipids; RCT; Sphingomyelin; Ultra-high risk.

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Conflict of interest statement

Declaration of competing interest Dr. McGorry reported receiving grant funding from National Alliance for Research on Schizophrenia and Depression and unrestricted research funding from AstraZeneca, Eli Lilly, Janssen-Cilag, Pfizer, and Novartis, as well as honoraria for educational activities with AstraZeneca, Eli Lilly, Janssen-Cilag, Pfizer, Bristol-Myers Squibb, Roche, and the Lundbeck Institute. Drs Nelson, Hickie, Yung, and Amminger have received National Health and Medical Research Council (NHMRC) funding. No other conflicts were reported.

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