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Editorial
. 2020 May;107(5):713-715.
doi: 10.1002/JLB.3CE0919-318R. Epub 2019 Oct 14.

Low Tregs: A targetable risk factor for life-threatening cardiovascular complications after major noncardiac surgery

Tin Kyaw  1   2 , Alex Bobik  1   2   3
Affiliations
Editorial

Low Tregs: A targetable risk factor for life-threatening cardiovascular complications after major noncardiac surgery

Tin Kyaw et al. J Leukoc Biol. 2020 May.

Abstract

Discussion on Tregs that have anti-inflammatory and anti-atherogenic properties as an ideal therapeutic target to reduce fatal cardiovascular deaths following major noncardiac surgery.

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References

REFERENCES

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    1. Bartels K, Karhausen J, Clambey ET, Grenz A, Eltzschig HK. Perioperative organ injury. Anesthesiology. 2013;119:1474-1489.
    1. Scholz AS, Handke J, Gillmann HJ, et al. Frontline science: low regulatory T cells predict perioperative major adverse cardiovascular and cerebrovascular events after noncardiac surgery. J Leukoc Biol. 2019. https://doi.org/10.1002/JLB.5HI1018-392RR
    1. Ait-Oufella H, Salomon BL, Potteaux S, et al. Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med. 2006;12:178-180.
    1. Fuijkschot WW, Morrison MC, van der Linden R, et al. Orthopedic surgery increases atherosclerotic lesions and necrotic core area in ApoE-/- mice. Atherosclerosis. 2016;255:164-170.

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