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. 2020 Oct;26(7):285-288.
doi: 10.1097/RHU.0000000000001104.

Frequency and Identification of Risk Factors of Uveitis in Juvenile Idiopathic Arthritis: A Long-term Follow-up Study in a Cohort of Italian Children

Giovanni Conti  1 , Valeria Chirico  1 , Federica Porcaro  1 , Claudia Fede  1 , Agata Vitale  1 , Antonio Fede  1 , Irene Castagna  2 , Carmelo Fede  1
Affiliations

Frequency and Identification of Risk Factors of Uveitis in Juvenile Idiopathic Arthritis: A Long-term Follow-up Study in a Cohort of Italian Children

Giovanni Conti et al. J Clin Rheumatol. 2020 Oct.

Abstract

Background: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood. The JIA-associated uveitis represents the most common extra-articular manifestation.

Objectives: The main aim of this study was to evaluate frequency and risk factors of uveitis in a pediatric population affected by JIA.

Methods: One hundred eight Italian children with JIA were followed during a follow-up period of 13 years. Association between uveitis, antinuclear antibodies (ANAs), and subtype of arthritis has been estimated, and Kaplan-Meier curves were generated to assess the probability of ocular complications during the follow-up period.

Results: Twenty-one patients developed uveitis, after 96.5 ± 50.4 months from the enrollment. According to JIA subtypes, the oligoarthritis subtype was characterized by the highest prevalence (39%) of uveitis. The greatest risk of uveitis has been detected in oligoarthritis patients associated to ANA positivity (risk ratio, 8.6; 95% confidence interval, 2.27-32.9; χ = 20.4), whereas the worst evolution was revealed in patients with oligoarthritis and high levels of ANAs, with a progression time of 36 months (log-rank χ = 16.39; p < 0.0001; risk ratio, 18; 95% confidence interval, 7.3-44.2).

Conclusions: Patients with early-onset ANA-positive oligoarticular JIA have the highest risk of developing uveitis. A routine ophthalmological follow-up is required at regular intervals, even though the joint disease is clinically quiescent.

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References

    1. Ravelli A, Martini A. Juvenile idiopathic arthritis. Lancet. 2007;369:767–778.
    1. Petty RE, Southwood TR, Manners P, et al; International League of Associations for Rheumatology. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol. 2004;31:390–392.
    1. Sen ES, Dick AD, Ramanan AV. Uveitis associated with juvenile idiopathic arthritis. Nat Rev Rheumatol. 2015;11:338–348.
    1. Lee DH, Daud U, Wipfl J, et al. The decreasing prevalence of uveitis associated with juvenile rheumatoid arthritis: do NSAIDs play a role?J Clin Rheumatol. 2003;9:151–155.
    1. Cassidy J, Kivlin J, Lindsley C, et al. The Section on Rheumatology and the Section on Ophthalmology. Ophthalmic examinations in children with juvenile rheumatoid arthritis. Pediatrics. 2006;117:1843–1845.

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