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. 2019 Dec 20;64(1):e01344-19.
doi: 10.1128/AAC.01344-19. Print 2019 Dec 20.

Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials

Sara Ceballos  1 , Choon Kim  2 , Yuanyuan Qian  2 , Shahriar Mobashery  2 , Mayland Chang  3 , Carmen Torres  4
Affiliations

Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials

Sara Ceballos et al. Antimicrob Agents Chemother. .

Abstract

The in vitro activities of five quinazolinone antibacterials, compounds Q1 to Q5, were tested against 210 strains of methicillin-resistant Staphylococcus aureus (MRSA). The MIC50/MIC90 values (in μg/ml) were as follows: Q1, 0.5/2; Q2, 1/4; Q3, 2/4; Q4, 0.06/0.25; and Q5, 0.125/0.5. Several strains with high MIC values (from 8 to >32 μg/ml) for some of these compounds exhibited amino acid changes in the penicillin-binding proteins, which are targeted by these antibacterials.

Keywords: MRSA; methicillin-resistant Staphylococcus aureus; penicillin-binding proteins; quinazolinones; staphylococci.

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Figures

FIG 1
FIG 1
Chemical structures of quinazolinones Q1 to Q5.
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References

    1. World Health Organization. 2014. Antimicrobial resistance: global report on surveillance. World Health Organization Press, Geneva, Switzerland.
    1. Centers for Disease Control and Prevention. 2013. Antibiotic resistance threats in the United States, 2013. Centers for Disease Control and Prevention, Atlanta, Georgia.
    1. Testero SA, Fisher JF, Mobashery S. 2010. β-Lactam antibiotics, p 259–404. In Abraham DJ, Rotella DP (ed), Burger’s medicinal chemistry, drug discovery and development, vol 7 John Wiley & Sons, Hoboken, NJ.
    1. Fuda C, Suvorov M, Vakulenko SB, Mobashery S. 2004. The basis for resistance to β-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. J Biol Chem 279:40802–40806. doi:10.1074/jbc.M403589200. - DOI - PubMed
    1. Zapun A, Contreras-Martel C, Vernet T. 2008. Penicillin-binding proteins and β-lactam resistance. FEMS Microbiol Rev 32:361–385. doi:10.1111/j.1574-6976.2007.00095.x. - DOI - PubMed

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