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. 2020 Feb;61(2):460-464.
doi: 10.1080/10428194.2019.1675876. Epub 2019 Oct 15.

Clonally-Related CD5+ CLL/SLL and CD10+ high grade B-cell lymphoma suggests common neoplastic progenitor with branched disease evolution, with therapeutic implications

Priyadarshini Kumar  1 , Manik Uppal  2 , Wenbin Xiao  1 , Ahmet Dogan  1 , Mikhail Roshal  1 , Qi Gao  1 , Umut Aypar  3 , Yanming Zhang  3 , Maria E Arcila  1   4 , Christine Moung  4 , Jinjuan Yao  4 , Khedoudja Nafa  4 , Wayne Yu  4 , Mustafa H Syed  4 , Jae Park  5 , Anita Kumar  6 , Caleb Ho  1   4
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Clonally-Related CD5+ CLL/SLL and CD10+ high grade B-cell lymphoma suggests common neoplastic progenitor with branched disease evolution, with therapeutic implications

Priyadarshini Kumar et al. Leuk Lymphoma. 2020 Feb.
No abstract available

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Figures

Figure 1.
Figure 1.
(a) Low power view showing hypercellular marrow. (b) High power view showing “blastoid” morphology in high grade B-cell lymphoma (HGBCL). (c) High power view showing CLL/SLL. (d) Aspirate smear showing dimorphic population of small lymphocytes with mature chromatin and large lymphoid cells with dispersed chromatin and prominent nucleoli. (e) Flow cytometric plots showing immunophenotype of HGBCL (orange) and CLL/SLL (blue). (f) SNP array findings in HGBCL showing homozygous deletion at 13q14.2 (including RB1 and SETDB2) and CN-LOH of 17p terminal to 17p11.2 (including TP53). (g) SNP array findings in CLL/SLL showing a 13q14.2 hemizygous deletion for RB1 and homozygous deletion for SETDB2 and loss of 17p13.1 to 17p12 (including TP53).
Figure 2.
Figure 2.
FISH findings on flow-sorted cells. (a) Loss of TP53 in 85% cells in CLL/SLL component. (b) No loss of TP53 in HGBCL component. (c) No MYC rearrangement in CLL/SLL component. (d) MYC rearrangement in 98% of cells in HGBCL component. (a–b) TP53 (17p13) probe (Red) and CEP17 (chr. 17 centromere) probe (Green). (c–d) MYC (8q24) break-apart probes.
See this image and copyright information in PMC

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