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Book

Toxic Megacolon

Ewelina Skomorochow  1 , Jose Pico  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Toxic Megacolon

Ewelina Skomorochow et al.
Free Books & Documents

Excerpt

Toxic megacolon is a rare but potentially deadly complication of colonic inflammation. Its definition is a nonobstructive dilation of the colon, which can be total or segmental and is usually associated with systemic toxicity. It is most commonly associated with inflammatory bowel disease, especially ulcerative colitis, yet any condition that leads to inflammation of the colon can potentially cause toxic megacolon.

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Conflict of interest statement

Disclosure: Ewelina Skomorochow declares no relevant financial relationships with ineligible companies.

Disclosure: Jose Pico declares no relevant financial relationships with ineligible companies.

References

    1. Jalan KN, Sircus W, Card WI, Falconer CW, Bruce CB, Crean GP, McManus JP, Small WP, Smith AN. An experience of ulcerative colitis. I. Toxic dilation in 55 cases. Gastroenterology. 1969 Jul;57(1):68-82. - PubMed
    1. Autenrieth DM, Baumgart DC. Toxic megacolon. Inflamm Bowel Dis. 2012 Mar;18(3):584-91. - PubMed
    1. Ausch C, Madoff RD, Gnant M, Rosen HR, Garcia-Aguilar J, Hölbling N, Herbst F, Buxhofer V, Holzer B, Rothenberger DA, Schiessel R. Aetiology and surgical management of toxic megacolon. Colorectal Dis. 2006 Mar;8(3):195-201. - PubMed
    1. Hommes DW, Sterringa G, van Deventer SJ, Tytgat GN, Weel J. The pathogenicity of cytomegalovirus in inflammatory bowel disease: a systematic review and evidence-based recommendations for future research. Inflamm Bowel Dis. 2004 May;10(3):245-50. - PubMed
    1. Norland CC, Kirsner JB. Toxic dilatation of colon (toxic megacolon): etiology, treatment and prognosis in 42 patients. Medicine (Baltimore) 1969 May;48(3):229-50. - PubMed

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