Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Oct 14;8(10):1248.
doi: 10.3390/cells8101248.

Nuclear-cytoplasmic Shuttling in Chronic Myeloid Leukemia: Implications in Leukemia Maintenance and Therapy

Giovanna Carrà  1 , Isabella Russo  2 , Angelo Guerrasio  3 , Alessandro Morotti  4
Affiliations
Review

Nuclear-cytoplasmic Shuttling in Chronic Myeloid Leukemia: Implications in Leukemia Maintenance and Therapy

Giovanna Carrà et al. Cells. .

Abstract

Nuclear-cytoplasmic shuttling is a highly regulated and complex process, which involves both proteins and nucleic acids. Changes in cellular compartmentalization of various proteins, including oncogenes and tumor suppressors, affect cellular behavior, promoting or inhibiting proliferation, apoptosis and sensitivity to therapies. In this review, we will recapitulate the role of various shuttling components in Chronic Myeloid Leukemia and we will provide insights on the potential role of shuttling proteins as therapeutic targets.

Keywords: BCR-ABL; PTEN; chronic myeloid leukemia; miRNA; nuclear-cytoplasmic shuttling; p53.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Fu X., Liang C., Li F., Wang L., Wu X., Lu A., Xiao G., Zhang G. The Rules and Functions of Nucleocytoplasmic Shuttling Proteins. Int. J. Mol. Sci. 2018;19:1445. doi: 10.3390/ijms19051445. - DOI - PMC - PubMed
    1. Chatterjee K., Nostramo R.T., Wan Y., Hopper A.K. tRNA dynamics between the nucleus, cytoplasm and mitochondrial surface: Location, location, location. Biochim. Et Biophys. Acta (Bba) - Gene Regul. Mech. 2018;1861:373–386. doi: 10.1016/j.bbagrm.2017.11.007. - DOI - PMC - PubMed
    1. Vindry C., Weil D., Standart N. Pat1 RNA-binding proteins: Multitasking shuttling proteins. Wiley Interdiscip. Rev.: RNA. 2019:e1557. doi: 10.1002/wrna.1557. - DOI - PubMed
    1. Conforti F., Wang Y., Rodriguez J.A., Alberobello A.T., Zhang Y.-W., Giaccone G. Molecular Pathways: Anticancer Activity by Inhibition of Nucleocytoplasmic Shuttling. Clin. Cancer Res. 2015;21:4508–4513. doi: 10.1158/1078-0432.CCR-15-0408. - DOI - PubMed
    1. Gravina G.L., Senapedis W., McCauley D., Baloglu E., Shacham S., Festuccia C. Nucleo-cytoplasmic transport as a therapeutic target of cancer. J. Hematol. Oncol. 2014;7 doi: 10.1186/s13045-014-0085-1. - DOI - PMC - PubMed

Publication types

MeSH terms