Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2019 Oct 15;19(1):205.
doi: 10.1186/s12886-019-1214-y.

Myopic Laser-Assisted Subepithelial Keratectomy (LASEK) outcomes using three different excimer laser platforms: a retrospective observational study

Isabel Rodríguez-Pérez  1   2 , Juan Gros-Otero  3 , Miguel A Teus  4   5 , Rafael Cañones  5 , Montserrat García-González  4   3
Affiliations
Observational Study

Myopic Laser-Assisted Subepithelial Keratectomy (LASEK) outcomes using three different excimer laser platforms: a retrospective observational study

Isabel Rodríguez-Pérez et al. BMC Ophthalmol. .

Abstract

Background: To compare the visual and refractive outcomes after myopic LASEK using three different excimer lasers and standardized surgical and mitomycin C (MMC) application protocols.

Methods: In this retrospective, observational cohort study, we examined 122 eyes treated with Allegretto, 135 eyes treated with Esiris and 137 eyes treated with Technolas excimer lasers. All eyes were treated under the same surgical protocol, and a standardized MMC dosage was used. The three groups were refraction-matched, and both visual and refractive outcomes were evaluated at 1 and 7 days and 1 and 3 months after surgery.

Results: At 3 months postsurgery, Allegretto provided significantly better outcomes than Esiris and Technolas in terms of postoperative uncorrected distance visual acuity (UDVA) (1.11 ± 0.2 vs 1.01 ± 0.2 vs 0.98 ± 0.2) (P = 0.0001), corrected distance visual acuity (CDVA) (1.13 ± 0.2 vs 1.10 ± 0.1 vs 1.04 ± 0.2) (P = 0.0001), residual sphere (- 0.01 ± 0.2 vs + 0.29 ± 0.7 vs + 0.27 ± 0.6) (P = 0.0001), and efficacy index (0.99 ± 0.2 vs 0.90 ± 0.2 vs 0.91 ± 0.2) (P = 0.0004).

Conclusions: We found slightly better visual and refractive outcomes in the Allegretto group at 3 months post-op after LASEK with MMC to correct myopia.

Keywords: Excimer laser; LASEK; Mitomycin C; Myopia.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Cumulative histogram of three-month uncorrected distance visual acuity after myopic LASEK with MMC of 394 eyes treated with the Allegretto, Esiris and Technolas excimer lasers. LASEK = Laser-assisted subepithelial keratomileusis; MMC = Mitomycin C; VA = Visual acuity. a- Allegretto, b- Esiris, c-Technolas
Fig. 2
Fig. 2
Changes in lines of corrected distance visual acuity at 3 months after myopic LASEK with MMC of 394 eyes treated with Allegretto, Esiris and Technolas excimer lasers. LASEK = Laser-assisted subepithelial keratomileusis; MMC = Mitomycin C; CDVA = Corrected distance visual acuity. a- Allegretto, b- Esiris, c-Technolas
Fig. 3
Fig. 3
Three-month predictability (SE ± 0.50 D and ± 1.00 D) after LASEK with MMC in the Allegretto, Esiris and Technolas groups for myopia correction. LASEK = Laser-assisted subepithelial keratomileusis; MMC = Mitomycin C; SE = Spherical Equivalent. a- Allegretto, b- Esiris, c-Technolas
Fig. 4
Fig. 4
Attempted versus achieved spherical equivalent refraction scatterplots at 3 months after LASEK with MMC for myopia correction in the Allegretto, Esiris and Technolas groups. The linear regression equation and coefficient of determination (r2) are displayed. LASEK = Laser-assisted subepithelial keratomileusis; MMC = Mitomycin C. a- Allegretto, b- Esiris, c-Technolas
See this image and copyright information in PMC

References

    1. de Benito-Llopis L, Teus MA, Sánchez-Pina JM, Hernández-Verdejo JL. Comparison between LASEK and LASIK for the correction of low myopia. J Refract Surg. 2007;23(2):139–145. - PubMed
    1. Teus MA, de Benito-Llopis L, Sanchez-Pina JM. LASEK versus LASIK for the correction of moderate myopia. Optom Vis Sci. 2007;84(7):605–610. - PubMed
    1. de Benito-Llopis L, Teus MA, Sánchez-Pina JM. Comparison between LASEK with mitomycin C and LASIK for the correction of myopia of −7.00 to −13.75 D. J Refract Surg. 2008;24(5):516–523. - PubMed
    1. Ambrosio R, Jr, Wilson S. LASIK vs LASEK vs PRK: advantages and indications. Semin Ophthalmol. 2003;18(1):2–10. - PubMed
    1. Dawson DG, Randleman JB, Grossniklaus HE, O’Brien TP, Dubovy SR, Schmack I, Stulting RD, Edelhauser HF. Corneal ectasia after excimer laser keratorefractive surgery: histopathology, ultrastructure, and pathophysiology. Ophthalmology. 2008;115(12):2181–2191. - PubMed

Publication types

LinkOut - more resources