Comment
doi: 10.1126/scisignal.aay8960.
Tuning the regulator: Phosphorylation of KCC2 at two specific sites is critical for neurodevelopment
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- PMID: 31615900
- DOI: 10.1126/scisignal.aay8960
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Comment
Tuning the regulator: Phosphorylation of KCC2 at two specific sites is critical for neurodevelopment
Sci Signal.
.
Abstract
The K+/Cl- cotransporter KCC2 is a molecular switch between excitatory and inhibitory effects of GABAergic inputs into neurons. In a pair of exciting studies, Watanabe et al. and Pisella et al. elucidate the role of KCC2 dephosphorylation in this process and reveal its consequences for neurodevelopment and nervous system pathology.
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Comment on
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Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology.Sci Signal. 2019 Oct 15;12(603):eaay0300. doi: 10.1126/scisignal.aay0300. Sci Signal. 2019. PMID: 31615899 Free PMC article.
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Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival.Sci Signal. 2019 Oct 15;12(603):eaaw9315. doi: 10.1126/scisignal.aaw9315. Sci Signal. 2019. PMID: 31615901 Free PMC article.
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