Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Aug 15:12:391-399.
doi: 10.2147/CEG.S175061. eCollection 2019.

Eosinophilic esophagitis: early diagnosis is the key

Amanda B Muir  1 , Terri Brown-Whitehorn  2 , Bridget Godwin  1 , Antonella Cianferoni  1
Affiliations

Eosinophilic esophagitis: early diagnosis is the key

Amanda B Muir et al. Clin Exp Gastroenterol. .

Abstract

Eosinophilic esophagitis (EoE) is a disorder which affects all ages, from infancy through adulthood. It typically affects atopic individuals (Table 1) and is a chronic allergic disorder, with foods ubiquitous in the diet being the most described trigger of this isolated eosinophilic inflammation of the esophagus in both adults and children. This inflammatory process leads to esophageal symptoms such as dysphagia and feeding intolerance. In this review, we provide a brief overview of the current state of EoE therapy and symptomatology and then try to make the case for early diagnosis and treatment to prevent some of the long-term consequences of esophageal inflammation.

Keywords: diagnosis; early; eosinophilic esophagitis; pain; stenosis.

PubMed Disclaimer

Conflict of interest statement

No conflicts of interest are declared by any of the authors in regard to this current publication.

References

    1. Kelly KJ, Lazenby AJ, Rowe PC, Yardley JH, Perman JA, Sampson HA. Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula. Gastroenterology. 1995;109:1503–1512. doi:10.1016/0016-5085(95)90637-1 - DOI - PubMed
    1. Warners MJ, van Rhijn BD, Verheij J, Smout A, Bredenoord AJ. Disease activity in eosinophilic esophagitis is associated with impaired esophageal barrier integrity. Am J Physiol Gastrointest Liver Physiol. 2017;313:G230–G238. doi:10.1152/ajpgi.00307.2016 - DOI - PubMed
    1. Spergel JM, Brown-Whitehorn TF, Cianferoni A, et al. Identification of causative foods in children with eosinophilic esophagitis treated with an elimination diet. J Allergy Clin Immunol. 2012;130:461–7 e5. doi:10.1016/j.jaci.2012.05.021 - DOI - PubMed
    1. Kagalwalla AF, Shah A, Li BU, et al. Identification of specific foods responsible for inflammation in children with eosinophilic esophagitis successfully treated with empiric elimination diet. J Pediatr Gastroenterol Nutr. 2011;53:145–149. doi:10.1097/MPG.0b013e31821cf503 - DOI - PubMed
    1. Cianferoni A, Shuker M, Brown-Whitehorn T, Hunter H, Venter C, Spergel JM. Food avoidance strategies in eosinophilic oesophagitis. Clin Exp Allergy. 2019;49:269–284. doi:10.1111/cea.13360 - DOI - PubMed