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Case Reports
. 2019 Sep 26;7(18):2899-2904.
doi: 10.12998/wjcc.v7.i18.2899.

Pleomorphic lipoma in the anterior mediastinum: A case report

Yu-Qiang Mao  1 , Xiao-Ying Liu  2 , Yun Han  3
Affiliations
Case Reports

Pleomorphic lipoma in the anterior mediastinum: A case report

Yu-Qiang Mao et al. World J Clin Cases. .

Abstract

Background: Pleomorphic lipoma (PL) is a rare benign mesenchymal tumor occurring predominantly in middle-aged and elderly men. It is typically found in the subcutaneous tissue of the posterior neck, back, and shoulders. There have also been a few reported cases in the face, scalp, and upper extremities. Currently, there is no report on its occurrence in the anterior mediastinum.

Case summary: Herein, we report the case of a 67-year-old woman diagnosed with PL in the anterior mediastinum. The tumor was removed by thoracoscopic surgery. There was no recurrence during the 24-mo follow-up period, and the prognosis was good. Most PL are located on the skin surface. However, they may also occur within the body, even in the mediastinum.

Conclusion: PL occurring in the anterior mediastinum is rare, and it may be differentiated from other tumors.

Keywords: Anterior mediastinum; Case report; Pleomorphic lipoma; Thoracoscopic surgery.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Chest computed tomography. A: Calcification was observed around some nodules; B: A fat-dense shadow could be seen in the anterior mediastinum. There was no enhancement observed by the enhanced computed tomography scan; C: Multiple variably sized fat-dense nodules.
Figure 2
Figure 2
Pathology examination. A: Intratumoral ossification; B: Atypical nuclei in the tumor; C: A small number of thick-walled blood vessels; D: Floret-like giant cells in the tumor; E: Spindle cells with mild nuclear atypia; F: Thick-walled vessels were observed; G: Immunohistochemical analysis for CD34 (+); H: Immunohistochemical analysis for vimentin (+). Magnification, ×400.
Figure 3
Figure 3
The tumor and cut surface. A: Poorly defined border between the tumor and pericardium; B: Multiple tumors in the anterior mediastinum; C: Cut surface was grayish yellow.
See this image and copyright information in PMC

References

    1. Hinds B, Agulló Pérez AD, LeBoit PE, McCalmont TH, North JP. Loss of retinoblastoma in pleomorphic fibroma: An immunohistochemical and genomic analysis. J Cutan Pathol. 2017;44:665–671. - PubMed
    1. Shi BJ, Jiang X, Xiao YJ, Wang SP, Hao J, Diao QC. Intradermal spindle cell/pleomorphic lipoma: Case report and review of the literature. Indian J Dermatol Venereol Leprol. 2017;83:692–696. - PubMed
    1. Shmookler BM, Enzinger FM. Pleomorphic lipoma: a benign tumor simulating liposarcoma. A clinicopathologic analysis of 48 cases. Cancer. 1981;47:126–133. - PubMed
    1. Weiss SW, Goldblum JR. Enzinger and Wei ss' s soft ti ssue tumors. 4th ed. Elsevier Science: Health Science Asia; 2002. pp. 597–601.
    1. Eggleston PA, Kagey-Sobotka A, Lichtenstein LM. A comparison of the osmotic activation of basophils and human lung mast cells. Am Rev Respir Dis. 1987;135:1043–1048. - PubMed

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