The Neuropeptide CGRP Induces Bipolar Syndrome in Group 2 Innate Lymphoid Cells

Yasutaka Motomura¹, Tetsuro Kobayashi², Kazuyo Moro³

Affiliations

¹ Laboratory for Innate Immune Systems, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka Suita-shi, Osaka 565-0871, Japan.
² Laboratory for Innate Immune Systems, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
³ Laboratory for Innate Immune Systems, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka Suita-shi, Osaka 565-0871, Japan; Laboratory for Innate Immune Systems, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan; Laboratory for Innate Immune Systems, Immunology Frontier Research Center (iFReC), Osaka University, 3-1, Yamadaoka Suita-shi, Osaka 565-0871, Japan. Electronic address: moro@ilc.med.osaka-u.ac.jp.

PMID: 31618650
DOI: 10.1016/j.immuni.2019.09.015

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Comment

The Neuropeptide CGRP Induces Bipolar Syndrome in Group 2 Innate Lymphoid Cells

Yasutaka Motomura et al. Immunity. 2019.

Free article

. 2019 Oct 15;51(4):598-600.

doi: 10.1016/j.immuni.2019.09.015.

Authors

Yasutaka Motomura¹, Tetsuro Kobayashi², Kazuyo Moro³

Affiliations

¹ Laboratory for Innate Immune Systems, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka Suita-shi, Osaka 565-0871, Japan.
² Laboratory for Innate Immune Systems, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
³ Laboratory for Innate Immune Systems, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka Suita-shi, Osaka 565-0871, Japan; Laboratory for Innate Immune Systems, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan; Laboratory for Innate Immune Systems, Immunology Frontier Research Center (iFReC), Osaka University, 3-1, Yamadaoka Suita-shi, Osaka 565-0871, Japan. Electronic address: moro@ilc.med.osaka-u.ac.jp.

PMID: 31618650
DOI: 10.1016/j.immuni.2019.09.015

Abstract

In this issue of Immunity, Nagashima et al., Wallrapp et al., and Xu et al. demonstrate that the neuropeptide calcitonin gene-related peptide (CGRP) fine tunes type 2 innate immune response via suppressing group 2 innate lymphoid cells (ILC2s).

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Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation.
Nagashima H, Mahlakõiv T, Shih HY, Davis FP, Meylan F, Huang Y, Harrison OJ, Yao C, Mikami Y, Urban JF Jr, Caron KM, Belkaid Y, Kanno Y, Artis D, O'Shea JJ. Nagashima H, et al. Immunity. 2019 Oct 15;51(4):682-695.e6. doi: 10.1016/j.immuni.2019.06.009. Epub 2019 Jul 25. Immunity. 2019. PMID: 31353223 Free PMC article.
Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses.
Wallrapp A, Burkett PR, Riesenfeld SJ, Kim SJ, Christian E, Abdulnour RE, Thakore PI, Schnell A, Lambden C, Herbst RH, Khan P, Tsujikawa K, Xavier RJ, Chiu IM, Levy BD, Regev A, Kuchroo VK. Wallrapp A, et al. Immunity. 2019 Oct 15;51(4):709-723.e6. doi: 10.1016/j.immuni.2019.09.005. Epub 2019 Oct 8. Immunity. 2019. PMID: 31604686 Free PMC article.
Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses.
Xu H, Ding J, Porter CBM, Wallrapp A, Tabaka M, Ma S, Fu S, Guo X, Riesenfeld SJ, Su C, Dionne D, Nguyen LT, Lefkovith A, Ashenberg O, Burkett PR, Shi HN, Rozenblatt-Rosen O, Graham DB, Kuchroo VK, Regev A, Xavier RJ. Xu H, et al. Immunity. 2019 Oct 15;51(4):696-708.e9. doi: 10.1016/j.immuni.2019.09.004. Immunity. 2019. PMID: 31618654 Free PMC article.

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The Neuropeptide CGRP Induces Bipolar Syndrome in Group 2 Innate Lymphoid Cells

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The Neuropeptide CGRP Induces Bipolar Syndrome in Group 2 Innate Lymphoid Cells

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