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Comment
. 2019 Oct 15;51(4):606-608.
doi: 10.1016/j.immuni.2019.09.018.

New Clones on the Block

Nandini Acharya  1 , Ana C Anderson  2
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Free article
Comment

New Clones on the Block

Nandini Acharya et al. Immunity. .
Free article

Abstract

Although immune checkpoint blockade (ICB) has yielded striking clinical responses in subsets of cancer patients, the mechanism of action is still unclear. In a recent issue of Nature Medicine, Yost et al., 2019 report that the T cell clones that dominate the intra-tumoral T cell landscape after ICB are distinct from those prior to treatment, a phenomenon referred to by the authors as "clonal replacement."

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  • Clonal replacement of tumor-specific T cells following PD-1 blockade.
    Yost KE, Satpathy AT, Wells DK, Qi Y, Wang C, Kageyama R, McNamara KL, Granja JM, Sarin KY, Brown RA, Gupta RK, Curtis C, Bucktrout SL, Davis MM, Chang ALS, Chang HY. Yost KE, et al. Nat Med. 2019 Aug;25(8):1251-1259. doi: 10.1038/s41591-019-0522-3. Epub 2019 Jul 29. Nat Med. 2019. PMID: 31359002 Free PMC article.

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