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Comment
. 2019 Nov;29(11):877-878.
doi: 10.1038/s41422-019-0240-x.

Nociceptor nerves set the stage for skin immunity

Felipe A Pinho-Ribeiro  1 , Isaac M Chiu  2
Affiliations
Comment

Nociceptor nerves set the stage for skin immunity

Felipe A Pinho-Ribeiro et al. Cell Res. 2019 Nov.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Nociceptor neurons drive anticipatory type 17 immunity in the skin. Skin infection or other noxious stimuli stimulate TRPV1+ nociceptor neurons to generate action potentials that travel orthodromically to the central nervous system and antidromically to adjacent nerve branches in an axonal reflex. These action potentials induce CGRP release from vesicles stored within nerve terminals at the site of infection and at neighboring sites of uninfected skin. CGRP acts on dermal dendritic cells to produce IL-23, which in turn induces γδ-T cells to produce IL-17 that mediates neutrophil recruitment to promote immunity against pathogens including S. aureus and C. albicans
See this image and copyright information in PMC

Comment on

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