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Comment
. 2019 Oct;574(7778):E8-E11.
doi: 10.1038/s41586-019-1623-3. Epub 2019 Oct 16.

Reversion after replacement of mitochondrial DNA

Gavin Hudson  1 , Yuko Takeda  2 , Mary Herbert  3   4
Affiliations
Comment

Reversion after replacement of mitochondrial DNA

Gavin Hudson et al. Nature. 2019 Oct.
No abstract available

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Comment on

  • Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations.
    Kang E, Wu J, Gutierrez NM, Koski A, Tippner-Hedges R, Agaronyan K, Platero-Luengo A, Martinez-Redondo P, Ma H, Lee Y, Hayama T, Van Dyken C, Wang X, Luo S, Ahmed R, Li Y, Ji D, Kayali R, Cinnioglu C, Olson S, Jensen J, Battaglia D, Lee D, Wu D, Huang T, Wolf DP, Temiakov D, Belmonte JC, Amato P, Mitalipov S. Kang E, et al. Nature. 2016 Dec 8;540(7632):270-275. doi: 10.1038/nature20592. Epub 2016 Nov 30. Nature. 2016. PMID: 27919073

References

    1. Greenfield, A. et al. Assisted reproductive technologies to prevent human mitochondrial disease transmission. Nat. Biotechnol. 35, 1059–1068 (2017). - DOI
    1. Kang, E. et al. Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations. Nature 540, 270–275 (2016). - DOI
    1. Yamada, M. et al. Genetic drift can compromise mitochondrial replacement by nuclear transfer in human oocytes. Cell Stem Cell 18, 749–754 (2016). - DOI
    1. Hyslop, L. A. et al. Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease. Nature 534, 383–386 (2016). - DOI
    1. Mackey, D. A. et al. Primary pathogenic mtDNA mutations in multigeneration pedigrees with Leber hereditary optic neuropathy. Am. J. Hum. Genet. 59, 481–485 (1996). - PubMed - PMC

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