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Case Reports
. 2019 Jul 17;6(7):e00115.
doi: 10.14309/crj.0000000000000115. eCollection 2019 Jul.

Glycogenic Hepatopathy

Bashar Sharma  1 , Marsha Antoine  1 , Mili Shah  1 , Rochelle Nagales Nagamos  2 , Savio John  3
Affiliations
Case Reports

Glycogenic Hepatopathy

Bashar Sharma et al. ACG Case Rep J. .

Abstract

Glycogenic hepatopathy is excessive intrahepatic glycogen accumulation. It is a rare complication of long-standing, poorly controlled type 1 diabetes mellitus. We report a case of a 19-year-old woman with a history of poorly controlled diabetes mellitus and frequent admissions for diabetic ketoacidosis, who presented with abdominal pain, nausea, vomiting, and hepatomegaly. She was found to have diabetic ketoacidosis with persistently elevated serum lactate that did not improve with insulin infusions. She eventually underwent a liver biopsy, which showed excessive intracytoplasmic glycogen accumulation consistent with glycogenic hepatopathy.

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Figures

Figure 1.
Figure 1.
(A) Hematoxylin and eosin (H&E) stain of needle core liver biopsy showing pale, swollen hepatocytes without significant inflammation. Glycated nucleus is seen at the bottom right (20×). (B) The portal tracts appear normal with no inflammatory infiltrates, imparting a preserved hepatic architecture on H&E stain (40×). (C) Periodic acid-Schiff stain highlighting the glycogen content within the hepatocytes (20×).
See this image and copyright information in PMC

References

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