Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Sep;36(3):192-200.
doi: 10.12701/yujm.2019.00269. Epub 2019 Aug 12.

Current status of stereotactic body radiotherapy for the treatment of hepatocellular carcinoma

Jongmoo Park  1 , Jae Won Park  2 , Min Kyu Kang  1
Affiliations
Review

Current status of stereotactic body radiotherapy for the treatment of hepatocellular carcinoma

Jongmoo Park et al. Yeungnam Univ J Med. 2019 Sep.

Abstract

Stereotactic body radiotherapy (SBRT) is an advanced form of radiotherapy (RT) with a growing interest on its application in the treatment of hepatocellular carcinoma (HCC). It can deliver ablative radiation doses to tumors in a few fractions without excessive doses to normal tissues, with the help of advanced modern RT and imaging technologies. Currently, SBRT is recommended as an alternative to curative treatments, such as surgery and radiofrequency ablation. This review discusses the current status of SBRT to aid in the decision making on how it is incorporated into the HCC management.

Keywords: Hepatocellular carcinoma; Image-guided radiotherapy; Radiotherapy; Stereotactic body radiotherapy.

PubMed Disclaimer

Conflict of interest statement

No potential conflicts of interest relevant to this article was reported.

Figures

Fig. 1.
Fig. 1.
An example of stereotactic body radiotherapy using tracking intensity-modulated beams for a 20-mm-sized lesion in segment 1 that occurred after right hepatectomy and 5 times of radiofrequency ablation. (A) Gold fiducial markers are inserted before the simulation for patient/tumor position verification and real-time tumor tracking. (B, C) Target volumes and normal tissues are delineated in breath-hold images, and then treatment plan using 9 intensity-modulated beams is generated (gross tumor volume in red, planning target volume in cyan, and the intestine in green). (D) In the treatment room, locations of fiducial markers are verified using cone-beam computed tomography. (E) The treatment beams are delivered while monitoring the movement of the fiducial markers in real time. Electronic portal imaging device shows the movement of each beamlet during tracking treatment. Images in B, C, and E are from this patient, and images in A and D are from other patients for demonstration.
See this image and copyright information in PMC

References

    1. Jung KW, Won YJ, Kong HJ, Lee ES, Community of Population-Based Regional Cancer Registries Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2015. Cancer Res Treat. 2018;50:303–16. - PMC - PubMed
    1. Perz JF, Armstrong GL, Farrington LA, Hutin YJ, Bell BP. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol. 2006;45:529–38. - PubMed
    1. Ock M, Choi WJ, Jo MW. Trend analysis of major cancer statistics according to sex and severity levels in Korea. PLoS One. 2018;13:e0203110. - PMC - PubMed
    1. European Association for the Study of the Liver EASL clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2018;69:182–236. - PubMed
    1. Korean Liver Cancer Association. National Cancer Center 2018 Korean Liver Cancer Association-National Cancer Center Korea Practice Guidelines for the management of hepatocellular Carcinoma. Gut Liver. 2019;13:227–99. - PMC - PubMed

LinkOut - more resources