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Review
. 2020 Oct;287(19):4170-4182.
doi: 10.1111/febs.15096. Epub 2019 Oct 31.

Pseudokinases: a tribble-edged sword

Laura Richmond  1 , Karen Keeshan  1
Affiliations
Free article
Review

Pseudokinases: a tribble-edged sword

Laura Richmond et al. FEBS J. 2020 Oct.
Free article

Abstract

Advances in the understanding of the Tribbles family of pseudokinases (TRIB1, TRIB2 and TRIB3) reveal these proteins as potentially valuable biomarkers of disease diagnosis, prognosis, prediction and clinical strategy. In their role as signalling mediators and scaffolding proteins, TRIBs lead to changes in protein stability and activity, which impact on diverse cellular processes such as proliferation, differentiation, cell cycle and cell death. We review the role of TRIB proteins as promising therapeutic targets, with an emphasis on their role in cancer, and as biomarkers, with potential application across diverse pathological processes.

Keywords: TRIB; biomarker; cancer; drug targeting; pseudokinase.

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References

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