Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Oct 17;14(10):e0223830.
doi: 10.1371/journal.pone.0223830. eCollection 2019.

Dietary acid load significantly predicts 10-years survival in patients underwent coronary artery bypass grafting (CABG) surgery

Mahdieh Abbasalizad Farhangi  1   2 , Mahdi Vajdi  3 , Mahdi Najafi  4   5   6
Affiliations

Dietary acid load significantly predicts 10-years survival in patients underwent coronary artery bypass grafting (CABG) surgery

Mahdieh Abbasalizad Farhangi et al. PLoS One. .

Abstract

Backgrounds: Numerous studies have revealed the role of dietary acid load as a potential risk factor for cardiovascular events and blood pressure. However, its role in predicting the mortality rate in patients underwent coronary artery bypass grafting surgery (CABG) has not been reported. In the current study we aimed to evaluate the relationship of dietary acid load and cardio-metabolic risk factors with ten year survival among patients underwent CABG.

Methods: The current prospective cohort study comprises 454 patients underwent CABG. Anthropometric, clinical and biochemical measurements were performed. Dietary acid load was calculated as either potential renal acid load (PRAL) or net endogenous acid production (NEPA) using the data obtained from a semi-quantitative food frequency questionnaire (FFQ). Survival analysis was performed using Kaplan-Meier method followed by log-rank test. The association between all-cause mortality and study parameters was performed with Cox-proportional hazard model.

Results: Patients in the higher PRAL and NEAP quartiles had lower BMI and lower ejection fraction rate (P <0.05). Moreover, lower hematocrit values were observed in patients of higher PRAL quartiles. Higher PRAL scores were associated with higher mortality rate and reduced survival days (adjusted hazard ratio: 1.023 (1.00-1.04; P-value = 0.01). However, there was no relationship between NEAP and survival.

Conclusions: We revealed that high PRAL scores are positive predictors of 10-year mortality in patients underwent CABG. The results of our study suggest that maintaining an adequate acid-base balance can contribute to longevity by reducing the risk of mortality.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. PRAL and estimated operation to survival (OS) after 10 years in patients underwent CABG.
Fig 2
Fig 2. NEAP and estimated operation to survival (OS) after 10 years in patients underwent CABG.
See this image and copyright information in PMC

References

    1. Naghavi M, Wang H, Lozano R, Davis A, Liang X, Zhou M, et al. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015. 10; 385(9963):117–171. 10.1016/S0140-6736(14)61682-2 - DOI - PMC - PubMed
    1. Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS medicine. 2006;3(11):e442 10.1371/journal.pmed.0030442 - DOI - PMC - PubMed
    1. World Health Organization (WHO). Cardiovascular Disease (CVDs) 2017:Availablefrom:http://www.who.int/mediacentre/factsheets/fs317/en/.
    1. Forouzanfar MH, Sepanlou SG, Shahraz S, BESc PN, Pourmalek F, Lozano R, et al. Evaluating causes of death and morbidity in Iran, global burden of diseases, injuries, and risk factors study 2010. Arch Iran Med. 2014; 17(5):304–20. doi: 0141705/AIM.004 - PubMed
    1. Fakhrzadeh H, Bandarian F, Adibi H, Samavat T, Malekafzali H, Hodjatzadeh E, et al. Coronary heart disease and associated risk factors in Qazvin: a population-based study. East Mediterr Health J 2008; 14:33–41. - PubMed