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Review
. 2020 Feb;25(2):330-343.
doi: 10.1016/j.drudis.2019.10.004. Epub 2019 Oct 14.

Regulating membrane lipid levels at the synapse by small-molecule inhibitors of monoacylglycerol lipase: new developments in therapeutic and PET imaging applications

Natasha L Grimsey  1 , Juha R Savinainen  2 , Bala Attili  3 , Muneer Ahamed  4
Affiliations
Review

Regulating membrane lipid levels at the synapse by small-molecule inhibitors of monoacylglycerol lipase: new developments in therapeutic and PET imaging applications

Natasha L Grimsey et al. Drug Discov Today. 2020 Feb.

Abstract

Monoacylglycerol lipase (MAGL) is a major endocannabinoid hydrolyzing enzyme and can be regulated to control endogenous lipid levels in the brain. This review highlights the pharmacological roles and in vivo PET imaging of MAGL in brain.

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