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Review
. 2019 Aug:50:28-34.
doi: 10.1016/j.mib.2019.09.005. Epub 2019 Oct 15.

Recoding the metagenome: microbiome engineering in situ

Travis Whitfill  1 , Julia Oh  2
Affiliations
Review

Recoding the metagenome: microbiome engineering in situ

Travis Whitfill et al. Curr Opin Microbiol. 2019 Aug.

Abstract

Synthetic biology has enabled a new generation of tools for engineering the microbiome, including targeted antibiotics, protein delivery, living biosensors and diagnostics, and metabolic factories. Here, we discuss opportunities and limitations in microbiome engineering, focusing on a new generation of tools for in situ genetic modification of a microbiome that hold particular promise in circumventing these limitations.

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