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Review
. 2019 Oct 16;7(4):151.
doi: 10.3390/vaccines7040151.

Next-Generation Whole-Cell Pneumococcal Vaccine

Victor Morais  1 , Esther Texeira  2 , Norma Suarez  3
Affiliations
Review

Next-Generation Whole-Cell Pneumococcal Vaccine

Victor Morais et al. Vaccines (Basel). .

Abstract

Streptococcus pneumoniae remains a major public health hazard. Although Pneumococcal Conjugate Vaccines (PCVs) are available and have significantly reduced the rate of invasive pneumococcal diseases, there is still a need for new vaccines with unlimited serotype coverage, long-lasting protection, and lower cost to be developed. One of the most promising candidates is the Whole-Cell Pneumococcal Vaccine (WCV). The new generation of whole-cell vaccines is based on an unencapsulated serotype that allows the expression of many bacterial antigens at a lower cost than a recombinant vaccine. These vaccines have been extensively studied, are currently in human trial phase 1/2, and seem to be the best treatment choice for pneumococcal diseases, especially for developing countries.

Keywords: RM200; Streptococcus pneumoniae; virulence factors; whole-cell vaccine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Development/genealogy of the RM200 serotype [46,47,48,50,54].
See this image and copyright information in PMC

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