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. 1988 Mar;42(3):498-505.

Efficient computations in multilocus linkage analysis

G M Lathrop  1 , J M Lalouel
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Efficient computations in multilocus linkage analysis

G M Lathrop et al. Am J Hum Genet. 1988 Mar.

Abstract

This paper describes efficient methods for likelihood calculations and maximum-likelihood estimation in multilocus linkage analysis of reference families and general disease pedigrees, and it documents their performance as implemented in the LINKAGE programs. This information should be of considerable value in determining computing needs for linkage investigations, and in evaluating the merits of alternative algorithms.

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References

    1. Hum Hered. 1971;21(6):523-42 - PubMed
    1. IMA J Math Appl Med Biol. 1984;1(1):31-49 - PubMed
    1. Nature. 1983 Nov 17-23;306(5940):234-8 - PubMed
    1. Hum Hered. 1983;33(5):291-301 - PubMed
    1. Am J Hum Genet. 1984 Mar;36(2):460-5 - PubMed

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