Structure Solves the Problem with Malaria Merozoite Vaccines

Patrick E Duffy¹

Affiliations

Affiliation

¹ Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: patrick.duffy@nih.gov.

PMID: 31623952
PMCID: PMC11131090
DOI: 10.1016/j.pt.2019.09.004

Comment

Structure Solves the Problem with Malaria Merozoite Vaccines

Patrick E Duffy. Trends Parasitol. 2019 Nov.

. 2019 Nov;35(11):855-857.

doi: 10.1016/j.pt.2019.09.004. Epub 2019 Oct 14.

Author

Patrick E Duffy¹

Affiliation

¹ Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: patrick.duffy@nih.gov.

PMID: 31623952
PMCID: PMC11131090
DOI: 10.1016/j.pt.2019.09.004

Abstract

Malaria vaccines targeting merozoite invasion of erythrocytes have long held appeal but failed in clinical trials. Three structural studies of antibody-antigen complexes by Alanine et al., Urusova et al., and Rawlinson et al. define neutralizing and nonneutralizing epitopes in essential invasion proteins, leading to rational design of improved merozoite vaccines.

Keywords: Plasmodium falciparum; Plasmodium vivax; X-ray crystallography; epitopes; malaria vaccine; neutralizing antibody.

Published by Elsevier Ltd.

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Structural basis for neutralization of Plasmodium vivax by naturally acquired human antibodies that target DBP.
Urusova D, Carias L, Huang Y, Nicolete VC, Popovici J, Roesch C, Salinas ND, Dechavanne S, Witkowski B, Ferreira MU, Adams JH, Gross ML, King CL, Tolia NH. Urusova D, et al. Nat Microbiol. 2019 Sep;4(9):1486-1496. doi: 10.1038/s41564-019-0461-2. Epub 2019 May 27. Nat Microbiol. 2019. PMID: 31133752 Free PMC article.
Structural basis for inhibition of Plasmodium vivax invasion by a broadly neutralizing vaccine-induced human antibody.
Rawlinson TA, Barber NM, Mohring F, Cho JS, Kosaisavee V, Gérard SF, Alanine DGW, Labbé GM, Elias SC, Silk SE, Quinkert D, Jin J, Marshall JM, Payne RO, Minassian AM, Russell B, Rénia L, Nosten FH, Moon RW, Higgins MK, Draper SJ. Rawlinson TA, et al. Nat Microbiol. 2019 Sep;4(9):1497-1507. doi: 10.1038/s41564-019-0462-1. Epub 2019 May 27. Nat Microbiol. 2019. PMID: 31133755 Free PMC article.
Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies.
Alanine DGW, Quinkert D, Kumarasingha R, Mehmood S, Donnellan FR, Minkah NK, Dadonaite B, Diouf A, Galaway F, Silk SE, Jamwal A, Marshall JM, Miura K, Foquet L, Elias SC, Labbé GM, Douglas AD, Jin J, Payne RO, Illingworth JJ, Pattinson DJ, Pulido D, Williams BG, de Jongh WA, Wright GJ, Kappe SHI, Robinson CV, Long CA, Crabb BS, Gilson PR, Higgins MK, Draper SJ. Alanine DGW, et al. Cell. 2019 Jun 27;178(1):216-228.e21. doi: 10.1016/j.cell.2019.05.025. Epub 2019 Jun 13. Cell. 2019. PMID: 31204103 Free PMC article.

References

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1. Alanine DGW et al. (2019) Human antibodies that slow erythrocyte invasion potentiate malaria-neutralizing antibodies. Cell 178, 216–228.e21 - PMC - PubMed

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Structure Solves the Problem with Malaria Merozoite Vaccines

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Structure Solves the Problem with Malaria Merozoite Vaccines

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