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doi: 10.1016/j.it.2019.09.001.
Epub 2019 Oct 14.
A TCR-Dependent Tissue Repair Potential of MAIT Cells
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- PMID: 31623980
- DOI: 10.1016/j.it.2019.09.001
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A TCR-Dependent Tissue Repair Potential of MAIT Cells
Trends Immunol.
2019 Nov.
Abstract
Three studies published in Cell Reports (Hinks et al., Lamichhane et al., and Leng et al.) describe the transcriptome of human and mouse mucosal-associated invariant T (MAIT) cells after cognate and noncognate stimulation. The results confirm the variability of MAIT cell effector functions and provide evidence of a new tissue-repair gene signature expressed upon T cell receptor (TCR) stimulation.
Copyright © 2019 Elsevier Ltd. All rights reserved.
Comment on
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TCR- or Cytokine-Activated CD8+ Mucosal-Associated Invariant T Cells Are Rapid Polyfunctional Effectors That Can Coordinate Immune Responses.Cell Rep. 2019 Sep 17;28(12):3061-3076.e5. doi: 10.1016/j.celrep.2019.08.054. Cell Rep. 2019. PMID: 31533031
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TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions.Cell Rep. 2019 Sep 17;28(12):3077-3091.e5. doi: 10.1016/j.celrep.2019.08.050. Cell Rep. 2019. PMID: 31533032 Free PMC article.
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Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality.Cell Rep. 2019 Sep 17;28(12):3249-3262.e5. doi: 10.1016/j.celrep.2019.07.039. Cell Rep. 2019. PMID: 31533045 Free PMC article.
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