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Case Reports
. 1988 Apr;31(2):271-4.
doi: 10.1016/0165-4608(88)90227-0.

Secondary leukemia with a translocation (8;21)?

S V Davies  1 , J A Murray, S M Bowser-Riley
Affiliations
Case Reports

Secondary leukemia with a translocation (8;21)?

S V Davies et al. Cancer Genet Cytogenet. 1988 Apr.

Abstract

The clinical features and cytogenetic changes of acute myeloid leukemia (AML) developing 10 years after radiotherapy and chemotherapy (for osteosarcoma) are described. Features of both de novo AML [FAB M2 morphology, t(8;21), and "secondary leukemia" (additional cytogenetic changes, resistance to chemotherapy) were present. The importance of differentiation between primary and "therapy-linked" disease, and the difficulties in making such a distinction, are discussed.

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