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. 2019 Oct 18;366(6463):302-303.
doi: 10.1126/science.aay7079.

Mobilizing unconventional T cells

Tom H M Ottenhoff  1 , Simone A Joosten  2
Affiliations

Mobilizing unconventional T cells

Tom H M Ottenhoff et al. Science. .
No abstract available

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Human leukocyte antigen-E in immunity
Under homeostatic conditions, HLA-E presents self-peptides and prevents NK cell–mediated lysis through the CD94-NKG2A axis, thus regulating innate immunity. In addition, HLA-E can present pathogen- or tumor-derived peptide antigens to unconventional CD8+ T cells, which recognize peptide–HLA-E complexes through specific TCRs, regulating adaptive immunity. HLA-E, human leukocyte antigen–E; NK cell, natural killer cell; NKG2A, NK group 2A; TCR, T cell receptor.
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References

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