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. 2020 Feb;40(2):263-268.
doi: 10.1038/s41372-019-0523-6. Epub 2019 Oct 17.

Survival trends and outcomes among preterm infants with congenital diaphragmatic hernia

Allison M Peluso  1 , Hasan F Othman  2 , Esraa M Elsamny  2 , Ibrahim Sammour  2 , Natalie K Yeaney  2 , Hany Aly  2
Affiliations

Survival trends and outcomes among preterm infants with congenital diaphragmatic hernia

Allison M Peluso et al. J Perinatol. 2020 Feb.

Abstract

Objective: The objective of this study was to use current national data to evaluate the characteristics and survival trends of preterm infants born with CDH from 2004 to 2014.

Study design: Data was queried from the National Inpatient Sample (NIS) and KID database from 2004 to 2014. Infants were included if diagnosed with CDH by ICD-9 coding and gestational age <37 weeks. Descriptive statistics, chi-square, and trend analysis were completed.

Results: We identified 2356 infants born prematurely with CDH. The overall survival rate was 49%. The survival range is 21.2-62.3% for gestational age <26 weeks to 35-36 weeks, respectively. Total mortality was 1183; of them, 1052 (89%) were not repaired and 363 (30.7%) did not receive mechanical ventilation. Surgical repair occurred in 55.1% of infants.

Conclusions: Preterm infants have lower survival compared with term infants. Survival rates decrease with lower gestational age and have improved over time.

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