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. 2019 Sep 16;3(4):564-565.
doi: 10.1002/rth2.12254. eCollection 2019 Oct.

Blood platelets: Circulating mirrors of neurons?

Affiliations

Blood platelets: Circulating mirrors of neurons?

Ilaria Canobbio. Res Pract Thromb Haemost. .
No abstract available

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Conflict of interest statement

The author has nothing to declare.

Figures

Figure 1
Figure 1
Schematic representation of platelets mirroring neurons. Neurons and platelets share common proteins (reelin, amyloid peptides, APP, BDNF, serotonin, and others). Alterations in metabolism of these proteins are related to neurological disorders and may be reflected in abnormalities in circulating platelets. APP, amyloid precursor protein; BDNF, brain‐derived neurotrophic factor

References

    1. Canobbio I, Guidetti GF, Torti M. Platelets in neurological disorders. In: Gresele P, Kleiman NS, Lopez JA, Page CP, editors. Platelets in thrombotic and non‐thrombotic disorders. Cham, Switzerland: Springer International; 2017.. p. 513–30.
    1. Tseng WL, Chen TH, Huang CC, Huang YH, Yeh CF, Tsai HJ, et al. Impaired thrombin generation in reelin‐deficient mice: a potential role of plasma Reelin in hemostasis. J Thromb Haemost. 2014;12:2054–64. - PubMed
    1. Gowert NS, Krüger I, Klier M, Donner L, Kipkeew F, Gliem M, et al. Loss of reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions. Cell Signal. 2017;40:210–21. - PubMed
    1. Van Nostrand WE, Schmaier AH, Farrow JS, Cunningham DD. Protease nexin‐II (amyloid beta‐protein precursor): a platelet alpha‐granule protein. Science. 1990;248:745–8. - PubMed
    1. Canobbio I, Visconte C, Momi S, Guidetti GF, Zarà M, Canino J, et al. Platelet amyloid precursor protein is a modulator of venous thromboembolism in mice. Blood. 2017;130:527–36. - PubMed