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. 2019 Sep;167(5):671-675.
doi: 10.1007/s10517-019-04596-9. Epub 2019 Oct 17.

VHL Expression in Kidney Cancer: Relation to Metastasis Development, Transcription and Growth Factors and Component of Akt/m-TOR Signaling Pathway

L V Spirina  1   2 , I V Kondakova  3 , Z A Yurmazov  3 , E A Usynin  3 , E M Slonimskaya  3   4 , N A Lushnikova  3 , D V Podnebesnova  4
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VHL Expression in Kidney Cancer: Relation to Metastasis Development, Transcription and Growth Factors and Component of Akt/m-TOR Signaling Pathway

L V Spirina et al. Bull Exp Biol Med. 2019 Sep.

Abstract

Von Hippel-Lindau protein (VHL) is associated with the development and progression of kidney cancer. An increase in VHL expression was found in patients with the disseminated form of the disease compared to the localized cancer, which was combined with a uniform distribution of decreased (<1.0) and increased (>1.0) VHL mRNA levels in renal cancer patients depending on the dissemination of the process. The increase in VHL expression was accompanied an increase in the level of mRNA for NF-κB p65 and kinases PDK1 and Akt. The revealed data indicate the importance of molecular biological parameters in oncogenesis.

Keywords: VHL; components of Akt/m-TOR signaling pathway; growth factors; kidney cancer; nuclear factors.

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