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Comment
. 2019 Oct 17;26(10):1335-1337.
doi: 10.1016/j.chembiol.2019.10.001.

Conquering Radicals with a Sense of Humor

Leo E Otterbein  1
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Free article
Comment

Conquering Radicals with a Sense of Humor

Leo E Otterbein. Cell Chem Biol. .
Free article

Abstract

In this issue of Cell Chemical Biology, Vasavda et al. (2019) present data supporting a neuroprotective role for bilirubin, a bioactive product resulting from heme degradation. While the antioxidant capability of bilirubin is well documented, its role in modulating superoxide radical signaling offers new insight into the regulation of neurotransmission and neuronal survival.

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  • Bilirubin Links Heme Metabolism to Neuroprotection by Scavenging Superoxide.
    Vasavda C, Kothari R, Malla AP, Tokhunts R, Lin A, Ji M, Ricco C, Xu R, Saavedra HG, Sbodio JI, Snowman AM, Albacarys L, Hester L, Sedlak TW, Paul BD, Snyder SH. Vasavda C, et al. Cell Chem Biol. 2019 Oct 17;26(10):1450-1460.e7. doi: 10.1016/j.chembiol.2019.07.006. Epub 2019 Jul 25. Cell Chem Biol. 2019. PMID: 31353321 Free PMC article.

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