doi: 10.1001/archpsyc.1979.01780130041005.
Color blindness not closely linked to bipolar illness. Report of a new pedigree series
- PMID: 316315
- DOI: 10.1001/archpsyc.1979.01780130041005
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Color blindness not closely linked to bipolar illness. Report of a new pedigree series
Arch Gen Psychiatry.
1979 Dec.
Abstract
A new pedigree series of bipolar manic-depressive patients admitted to the National Institute of Mental Health intramural research program was evaluated for linkage between bipolar illness and red-green color blindness, since previous studies had indicated that close linkage was generally present. Using family study methods, six informative pedigrees were investigated. Analysis was performed using a multigenerational procedure and taking into account variable penetrance. Close linkage could be definitively ruled out as a general finding. Bipolar and related illnesses are thus not generally transmitted by a single major gene close to the protan/deutan region of the human X-chromosome.
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