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Review
. 2019 Oct 25;36(5):885-892.
doi: 10.7507/1001-5515.201903012.

[Advances in the mouse models of myeloid leukemia]

[Article in Chinese]
Chentao Ge  1 , Caiyun Fu  1
Affiliations
Review

[Advances in the mouse models of myeloid leukemia]

[Article in Chinese]
Chentao Ge et al. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. .

Abstract
in English, Chinese

Mouse animal models are the most commonly used experimental tools in scientific research, which have been widely favored by researchers. The animal model of mouse leukemia appeared in the 1930s. During the past 90 years, researchers have developed various types of mouse leukemia models to simulate the development and treatment of human leukemia in order to promote effectively the elucidation of the molecular mechanism of leukemia' development and progression, as well as the development of targeted drugs for the treatment of leukemia. Considering that to myeloid leukemia, especially acute myeloid leukemia, there currently is no good clinical treatment, it is urgent to clarify its new molecular mechanism and develop new therapeutic targets. This review focuses on the various types of mouse models about myeloid leukemia used commonly in recent years, including mouse strains, myeloid leukemia cell types, and modeling methods, which are expected to provide a reference for relevant researchers to select animal models during myeloid leukemia research.

小鼠动物模型作为科学研究中最常用的实验工具，在两个世纪的发展中受到了研究人员的广泛青睐。小鼠白血病动物模型出现于 20 世纪 30 年代，在近 90 年的发展过程中，研究者们开发出了多种类型的小鼠白血病模型来模拟人类白血病的发生发展和药物治疗过程，这在一定程度上推动了白血病发生发展分子机制的阐明和靶向治疗白血病药物的研发进程。考虑到髓系白血病，特别是急性髓系白血病目前在临床上没有很好的治疗措施，急需阐明其新的分子机制和开发新的治疗靶点，本文重点综述了近几年最常用的髓系白血病小鼠模型，包括小鼠品系、髓系白血病细胞类型、成模方式等，以期为相关科研工作者在髓系白血病研究过程中选择动物模型时提供一定的参考。.

Keywords: mouse strains; myeloid leukemia; patient derived xenograft model; xenograft models.

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Conflict of interest statement

利益冲突声明：本文全体作者均声明不存在利益冲突。

Figures

图 1
图 1
Common mouse models of leukemia 常用的白血病小鼠模型
See this image and copyright information in PMC

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