Positive-end expiratory pressure titration and transpulmonary pressure: the EPVENT 2 trial

doi:10.21037/jtd.2019.06.34

Editorial

. 2019 Sep;11(Suppl 15):S2012-S2017.

doi: 10.21037/jtd.2019.06.34.

Positive-end expiratory pressure titration and transpulmonary pressure: the EPVENT 2 trial

Emanuele Turbil¹, Louis Marie Galerneau^{2

3}, Nicolas Terzi^{2

3}, Carole Schwebel^{2

3}, Laurent Argaud^{4

5}, Claude Guérin^{5

6}

Affiliations

¹ Anesthesiology and Intensive Care, Università degli Studi di Sassari, Sassari, Italy.
² Medical ICU, University Hospital, Grenoble, France.
³ University of Grenoble-Alpes, Grenoble, France.
⁴ Medical ICU, University Hospital Lyon Center, Lyon, France.
⁵ University of Lyon, Lyon, France.
⁶ INSERM 955, Créteil, France.

PMID: 31632813
PMCID: PMC6783739
DOI: 10.21037/jtd.2019.06.34

Editorial

Positive-end expiratory pressure titration and transpulmonary pressure: the EPVENT 2 trial

Emanuele Turbil et al. J Thorac Dis. 2019 Sep.

. 2019 Sep;11(Suppl 15):S2012-S2017.

doi: 10.21037/jtd.2019.06.34.

Authors

Emanuele Turbil¹, Louis Marie Galerneau^{2

3}, Nicolas Terzi^{2

3}, Carole Schwebel^{2

3}, Laurent Argaud^{4

5}, Claude Guérin^{5

6}

Affiliations

¹ Anesthesiology and Intensive Care, Università degli Studi di Sassari, Sassari, Italy.
² Medical ICU, University Hospital, Grenoble, France.
³ University of Grenoble-Alpes, Grenoble, France.
⁴ Medical ICU, University Hospital Lyon Center, Lyon, France.
⁵ University of Lyon, Lyon, France.
⁶ INSERM 955, Créteil, France.

PMID: 31632813
PMCID: PMC6783739
DOI: 10.21037/jtd.2019.06.34

No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

**Figure 1**
Mean values of partial pressure of arterial oxygen (PaO₂) to fraction of inspired oxygen in air (FiO₂) ratio, prevalence of pneumonia, and mortality at the last follow-up in the trial in the control groups of recent randomized control trials in acute respiratory distress patients. The studies are shown in alphabetic order in each plot and the references are (5-7,9,11,15-18).

**Figure 2**
Mean values of positive end expiratory pressure (PEEP) in the lower panels and Plateau pressure (Pplat) in the upper panels for control (right panels) and intervention groups (left panels) recent randomized control trials in acute respiratory distress patients. The studies are shown in alphabetic order in each plot and the references are (5-7,9,11,15-18).

See this image and copyright information in PMC

Comment on

Effect of Titrating Positive End-Expiratory Pressure (PEEP) With an Esophageal Pressure-Guided Strategy vs an Empirical High PEEP-Fio2 Strategy on Death and Days Free From Mechanical Ventilation Among Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial.
Beitler JR, Sarge T, Banner-Goodspeed VM, Gong MN, Cook D, Novack V, Loring SH, Talmor D; EPVent-2 Study Group. Beitler JR, et al. JAMA. 2019 Mar 5;321(9):846-857. doi: 10.1001/jama.2019.0555. JAMA. 2019. PMID: 30776290 Free PMC article. Clinical Trial.

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References

1. Ranieri VM, Rubenfeld GD, Thompson BT, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA 2012;307:2526-33. - PubMed
1. Ashbaugh DG, Bigelow DB, Petty TL, et al. Acute respiratory distress in adults. Lancet 1967;2:319-23. 10.1016/S0140-6736(67)90168-7 - DOI - PubMed
1. Bellani G, Laffey JG, Pham T, et al. Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA 2016;315:788-800. 10.1001/jama.2016.0291 - DOI - PubMed
1. Acute Respiratory Distress Syndrome Network , Brower RG, Matthay MA, et al. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 2000;342:1301-8. 10.1056/NEJM200005043421801 - DOI - PubMed
1. Brower RG, Lanken PN, MacIntyre N, et al. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 2004;351:327-36. 10.1056/NEJMoa032193 - DOI - PubMed

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[1] Ranieri VM, Rubenfeld GD, Thompson BT, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA 2012;307:2526-33. - PubMed

[2] Ranieri VM, Rubenfeld GD, Thompson BT, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA 2012;307:2526-33. - PubMed

[3] Ashbaugh DG, Bigelow DB, Petty TL, et al. Acute respiratory distress in adults. Lancet 1967;2:319-23. 10.1016/S0140-6736(67)90168-7 - DOI - PubMed

[4] Ashbaugh DG, Bigelow DB, Petty TL, et al. Acute respiratory distress in adults. Lancet 1967;2:319-23. 10.1016/S0140-6736(67)90168-7 - DOI - PubMed

[5] Bellani G, Laffey JG, Pham T, et al. Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA 2016;315:788-800. 10.1001/jama.2016.0291 - DOI - PubMed

[6] Bellani G, Laffey JG, Pham T, et al. Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA 2016;315:788-800. 10.1001/jama.2016.0291 - DOI - PubMed

[7] Acute Respiratory Distress Syndrome Network , Brower RG, Matthay MA, et al. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 2000;342:1301-8. 10.1056/NEJM200005043421801 - DOI - PubMed

[8] Acute Respiratory Distress Syndrome Network , Brower RG, Matthay MA, et al. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 2000;342:1301-8. 10.1056/NEJM200005043421801 - DOI - PubMed

[9] Brower RG, Lanken PN, MacIntyre N, et al. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 2004;351:327-36. 10.1056/NEJMoa032193 - DOI - PubMed

[10] Brower RG, Lanken PN, MacIntyre N, et al. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 2004;351:327-36. 10.1056/NEJMoa032193 - DOI - PubMed

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Positive-end expiratory pressure titration and transpulmonary pressure: the EPVENT 2 trial

Affiliations

Positive-end expiratory pressure titration and transpulmonary pressure: the EPVENT 2 trial

Authors

Affiliations

Conflict of interest statement

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