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Case Reports
. 2019 Feb 28;3(5):435-437.
doi: 10.1002/jgh3.12156. eCollection 2019 Oct.

Thrombotic thrombocytopenic purpura: A rare complication of acute pancreatitis

Jimil Shah  1 , Harshal S Mandavdhare  1 , Chhagan Lal Birda  1 , Usha Dutta  1 , Vishal Sharma  1
Affiliations
Case Reports

Thrombotic thrombocytopenic purpura: A rare complication of acute pancreatitis

Jimil Shah et al. JGH Open. .

Abstract

Thrombotic Thrombocytopenic Purpura (TTP) is a poorly understood entity involving multiple organs and having grave prognosis if not treated promptly. Acute pancreatitis (AP) is a rare cause of TTP and TTP is also a rare complication of acute pancreatitis. TTP is induced in AP by poorly understood mechanism, which involves multiple pathways apart from only ADAMTS13 deficiency. Here, we report a case of a 32-year-old male who developed acute pancreatitis due to chronic alcoholism. He developed signs of TTP from Day 4 of his onset of pain. High clinical suspicion and prompt initiation of plasmapheresis was associated with good outcome. In this case report, we have discussed details of our case and the different mechanisms involved in pathogenesis of TTP in AP and their outcome with prompt management.

Keywords: TTP; delirium; pancreatitis; renal failure.

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Figures

Figure 1
Figure 1
CECT abdomen of patient showing interstitial pancreatitis
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