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Review
. 2019 Nov:49:364-373.
doi: 10.1016/j.ebiom.2019.09.057. Epub 2019 Oct 18.

Systems biology perspective for studying the gut microbiota in human physiology and liver diseases

Ozlem Altay  1 , Jens Nielsen  2 , Mathias Uhlen  3 , Jan Boren  4 , Adil Mardinoglu  5
Affiliations
Review

Systems biology perspective for studying the gut microbiota in human physiology and liver diseases

Ozlem Altay et al. EBioMedicine. 2019 Nov.

Abstract

The advancement in high-throughput sequencing technologies and systems biology approaches have revolutionized our understanding of biological systems and opened a new path to investigate unacknowledged biological phenomena. In parallel, the field of human microbiome research has greatly evolved and the relative contribution of the gut microbiome to health and disease have been systematically explored. This review provides an overview of the network-based and translational systems biology-based studies focusing on the function and composition of gut microbiota. We also discussed the association between the gut microbiome and the overall human physiology, as well as hepatic diseases and other metabolic disorders.

Keywords: Biomarker; Gut microbiome; Host-microbiome interactions; Liver diseases; Meta-omics; Metabolic models; Personalized medicine; Systems biology.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Recent systems biology studies elucidate the close connection between gut microbiota and liver. Upper part of the figure reflects the healthy state of liver-gut axis. Alterations in the microbial composition and impaired intestinal barrier elucidated as pathogenic factors in various types of liver diseases by recent systems biology studies. (NAFLD/ALD, non-alcoholic fatty liver disease/alcoholic liver disease; NASH, non-alcoholic hepatosteatosis; HCC, hepatocellular cancer).
Fig. 2
Fig. 2
Interactions between human gut and liver have been deciphered by various omics technologies. Systems biology methodologies integrate high-throughput omics data to develop high-quality translational research and personalized medicine.
See this image and copyright information in PMC

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