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. 2019 Oct 4:9:981.
doi: 10.3389/fonc.2019.00981. eCollection 2019.

Diagnostic Accuracy of Multi-Parametric Magnetic Resonance Imaging for Tumor Staging of Bladder Cancer: Meta-Analysis

Nieke Zhang  1 , Xiaoyan Wang  2 , Chunying Wang  2 , Shuqiu Chen  1 , Jianping Wu  1 , Guangyuan Zhang  1 , Weidong Zhu  1 , Jing Liu  1 , Bin Xu  1 , Mulong Du  3   4 , Ming Chen  1
Affiliations

Diagnostic Accuracy of Multi-Parametric Magnetic Resonance Imaging for Tumor Staging of Bladder Cancer: Meta-Analysis

Nieke Zhang et al. Front Oncol. .

Abstract

Purpose: Evaluate the diagnostic accuracy of multi-parametric magnetic resonance imaging (mp-MRI) for local staging of bladder cancer (BCa). Materials and Methods: The databases of PubMed, Web of Science, Wanfang, and CNKI were searched for related literatures about BCa diagnosed by mp-MRI from January 1, 2000 to April 12, 2019. The strict inclusion and exclusion criteria were set up to extract records. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS)-2 was used to evaluate quality of the candidate studies. The pooled sensitivity, specificity, positive likelihood ratio (+LR), negative likelihood ratio (-LR), and diagnostic odds ratio (DOR) were calculated to assess the diagnostic authenticity of mp-MRI. The summarized receiver operating characteristic (SROC) curve corresponding with the area under the curve (AUC) were analyzed to comprehensively evacuate the diagnostic value of mp-MRI. Results: A total of 140 studies were retrieved by computer-based searching. After quality control, 4 studies with 259 patients were enrolled for meta-analysis. The pooled results showed 0.84 of sensitivity [95% confidence interval (CI) = 0.79-0.89], 0.91 of specificity (95% CI = 0.87-0.93), 8.24 of +LR (95% CI = 4.87-13.92), 0.18 of -LR (95% CI = 0.10-0.31), 49.42 of DOR (95% CI = 19.07-128.09), and 0.946 of AUC. The Spearman correlation analysis found no threshold effect (p = 0.684). A significant heterogeneity existed among 4 included studies with sensitivity (I2 = 65.7%), specificity (I 2 = 60.0%) and diagnostic OR (I 2 = 67.5%). The Begg's test (p = 0.497) and the egger's test (p = 0.337) found no publication bias. Conclusion: mp-MRI acts a good diagnostic performance for bladder cancer. It is plausible that mpMRIs can be used as an important method for bladder cancer staging.

Keywords: bladder cancer; diagnosis; meta-analysis; multi-parametric magnetic resonance imaging; staging.

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Figures

Figure 1
Figure 1
Flow diagram showing study selection process for meta-analysis.
Figure 2
Figure 2
Grouped bar charts show risk of bias and applicability concerns of 4 included records using QUADAS-2.
Figure 3
Figure 3
Forest plots of pooled sensitivity, specificity, and diagnostic OR.
Figure 4
Figure 4
Forest plots of pooled SROC Curve.
Figure 5
Figure 5
Plots of Egger's and Begg's test.
See this image and copyright information in PMC

References

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 Countries. CA Cancer J Clin. (2018) 68:394–424. 10.3322/caac.21492 - DOI - PubMed
    1. Chavan S, Bray F, Lortet-Tieulent J, Goodman M, Jemal A. International variations in bladder cancer incidence and mortality. Eur Urol. (2014) 66:59–73. 10.1016/j.eururo.2013.10.001 - DOI - PubMed
    1. Degeorge KC, Holt HR, Hodges SC. Bladder cancer: diagnosis and treatment. Am Fam Phys. (2017) 96:507–14. - PubMed
    1. de Haas RJ, Steyvers MJ, Futterer JJ. Multiparametric MRI of the bladder: ready for clinical routine? Am J Roentgenol. (2014) 202:1187–95. 10.2214/AJR.13.12294 - DOI - PubMed
    1. Whiting PF, Rutjes AW, Westwood ME, Mallett S, Deeks JJ, Reitsma JB, et al. . QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med. (2011) 155:529–36. 10.7326/0003-4819-155-8-201110180-00009 - DOI - PubMed

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