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Review
. 2019 Nov;25(11):e3210.
doi: 10.1002/psc.3210. Epub 2019 Oct 21.

Bacterial resistance to antimicrobial peptides

Milad Abdi  1   2 , Shiva Mirkalantari  2 , Nour Amirmozafari  2
Affiliations
Review

Bacterial resistance to antimicrobial peptides

Milad Abdi et al. J Pept Sci. 2019 Nov.

Abstract

Antimicrobial peptides (AMPs) or host defense peptides (HDPs) are vital components of human innate defense system targeting human-related bacteria. Many bacteria have various mechanisms interfering with AMP activity, causing resistance to AMPs. Since AMPs are considered as potential novel antimicrobial drugs, understanding the mechanisms of bacterial resistance to direct killing of AMPs is of great significance. In this review, a comparative overview of bacterial strategies for resistance to direct killing of various AMPs is presented. Such strategies include bacterial cell envelope modification, AMP degradation, sequestration, expelling, and capsule.

Keywords: AMPs; antimicrobial peptides; bacterial resistance; host defense peptides.

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References

REFERENCES

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