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. 2019 Nov 1;21(21):8572-8576.
doi: 10.1021/acs.orglett.9b03148. Epub 2019 Oct 22.

Catalytic Asymmetric Aza-Friedel-Crafts-Type Reaction of Indoles with Isatin-Derived N-Cbz-Ketimines Using a Chiral Bis(Imidazolidine)-Containing NCN-Pincer Palladium Catalyst

Takayoshi Arai  1 , Kensuke Araseki  1 , Junki Kakino  1
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Catalytic Asymmetric Aza-Friedel-Crafts-Type Reaction of Indoles with Isatin-Derived N-Cbz-Ketimines Using a Chiral Bis(Imidazolidine)-Containing NCN-Pincer Palladium Catalyst

Takayoshi Arai et al. Org Lett. .

Abstract

A chiral bis(imidazolidine)-containing NCN-pincer palladium complex (tBu-PhBidine-Pd-OTf) was an efficient catalyst for the aza-Friedel-Crafts-type reaction of 1H-indoles with isatin-derived N-Cbz-ketimines to give chiral 3-aminobisindole compounds having differently oxidized indole units with high enantioselectivities.

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