Broad Genetic Testing in a Clinical Setting Uncovers a High Prevalence of Titin Loss-of-Function Variants in Very Early Onset Atrial Fibrillation

William R Goodyer^{1

2}, Kyla Dunn³, Colleen Caleshu³, Mary Jackson³, Jennifer Wylie³, Tia Moscarello³, Julia Platt³, Chloe Reuter³, Allysonne Smith³, Anthony Trela², Scott R Ceresnak², Kara S Motonaga², Euan Ashley^{1

3

4}, Phillip Yang^{1

4}, Anne M Dubin², Marco Perez^{1

3

4}

Affiliations

¹ Cardiovascular Institute, Stanford University (W.R.G., E.A., P.Y., M.P.).
² Division of Pediatric Cardiology, Department of Pediatrics, Lucille Packard Children's Hospital (W.R.G., A.T., S.R.C., K.S.M., A.M.D.).
³ Stanford Center for Inherited Cardiovascular Disease (K.D., C.C., M.J., J.W., T.M., J.P., C.R., A.S., E.A., M.P.).
⁴ Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, CA (E.A., P.Y., M.P.).

William R Goodyer et al. Circ Genom Precis Med. 2019 Nov.

. 2019 Nov;12(11):e002713.

doi: 10.1161/CIRCGEN.119.002713. Epub 2019 Oct 22.

¹ Cardiovascular Institute, Stanford University (W.R.G., E.A., P.Y., M.P.).
² Division of Pediatric Cardiology, Department of Pediatrics, Lucille Packard Children's Hospital (W.R.G., A.T., S.R.C., K.S.M., A.M.D.).
³ Stanford Center for Inherited Cardiovascular Disease (K.D., C.C., M.J., J.W., T.M., J.P., C.R., A.S., E.A., M.P.).
⁴ Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, CA (E.A., P.Y., M.P.).

No abstract available

Keywords: atrial fibrillation; cardiomyopathies; comorbidity; genetic testing; heart failure.

References

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