Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Nov 1;21(21):8857-8860.
doi: 10.1021/acs.orglett.9b03565. Epub 2019 Oct 22.

2,2-Bifunctionalization of Norbornene in Palladium-Catalyzed Domino Annulation

Si-Yi Yang  1 , Wen-Yong Han  1 , Chen He  1 , Bao-Dong Cui  1 , Nan-Wei Wan  1 , Yong-Zheng Chen  1
Affiliations

2,2-Bifunctionalization of Norbornene in Palladium-Catalyzed Domino Annulation

Si-Yi Yang et al. Org Lett. .

Abstract

A palladium-catalyzed three-component [2 + 3 + 1] domino annulation among 3-iodochromones, α-bromoacetophenones, and norbornene is presented, affording various chromone-containing polycyclic compounds bearing fused/spiro/bridged-ring systems. For the first time, the 2,2-bifunctionalization of norbornene was realized in palladium-catalyzed domino reaction. This cyclization characterizes three new bonds (two C-C and one C-O) in a single operation and produces nontrivial spiro-norbornane fragments in comparison with a traditional palladium-catalyzed process involving norbornene.

PubMed Disclaimer

Publication types

LinkOut - more resources