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. 2019 Dec 1;69(4):673-681.
doi: 10.2478/acph-2019-0037.

Phenolic compounds of Iris adriatica and their antimycobacterial effects

Sandra Ochensberger  1 , Fabian Alperth  1 , Božena Mitić  2 , Olaf Kunert  3 , Stefanie Mayer  1 , Maria Ferreira Mourão  4 , Ivana Turek  1 , Simon Vlad Luca  5 , Krystyna Skalicka-Woźniak  6 , Željan Maleš  7 , Dario Hruševar  2 , Ivan Duka  7 , Franz Bucar  1
Affiliations
Free article

Phenolic compounds of Iris adriatica and their antimycobacterial effects

Sandra Ochensberger et al. Acta Pharm. .
Free article

Abstract

Little is known about the pharmacological activities of Iris adriatica (Iridaceae), a plant endemic to Dalmatia (Croatia). We therefore performed a bioassay-guided fractionation including high-performance counter current chromatography (HPCCC) and antibacterial tests using Mycobacterium smegmatis mc2 155. One obtained fraction was found to be antimycobacterially active with a MIC of 64 mg L-1. Furthermore, fractions were tested for resistance modulatory effects using ethidium bromide as substrate. We were able to identify the pure isoflavonic compounds irigenin and irilone and a fraction containing mainly benzophenone 2,4,6-trihydroxy-4-methoxy-benzophenone, responsible for the resistance-modulatory activity of this plant.

Keywords: Iris adriatica; MIC; Mycobacterium smegmatis; Radix Iridis; ethidium bromide; phenolic compounds; resistance modulation.

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References

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