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Review
. 2019 Oct 22;19(1):869.
doi: 10.1186/s12879-019-4420-6.

Pneumonia due to Pandoraea Apista after evacuation of traumatic intracranial hematomas:a case report and literature review

Chuanzhong Lin  1   2 , Ning Luo  1 , Qiang Xu  2 , Jianjun Zhang  3 , Mengting Cai  4 , Guanhao Zheng  5 , Ping Yang  6
Affiliations
Review

Pneumonia due to Pandoraea Apista after evacuation of traumatic intracranial hematomas:a case report and literature review

Chuanzhong Lin et al. BMC Infect Dis. .

Abstract

Background: Pandoraea species is a newly described genus, which is multidrug resistant and difficult to identify. Clinical isolates are mostly cultured from cystic fibrosis (CF) patients. CF is a rare disease in China, which makes Pandoraea a total stranger to Chinese physicians. Pandoraea genus is reported as an emerging pathogen in CF patients in most cases. However, there are few pieces of evidence that confirm Pandoraea can be more virulent in non-CF patients. The pathogenicity of Pandoraea genus is poorly understood, as well as its treatment. The incidence of Pandoraea induced infection in non-CF patients may be underestimated and it's important to identify and understand these organisms.

Case presentation: We report a 44-years-old man who suffered from pneumonia and died eventually. Before his condition deteriorated, a Gram-negative bacilli was cultured from his sputum and identified as Pandoraea Apista by matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS).

Conclusion: Pandoraea spp. is an emerging opportunistic pathogen. The incidences of Pandoraea related infection in non-CF patients may be underestimated due to the difficulty of identification. All strains of Pandoraea show multi-drug resistance and highly variable susceptibility. To better treatment, species-level identification and antibiotic susceptibility test are necessary.

Keywords: Brain trauma; Pandoraea Apista; Pathogenicity; Pneumonia; Susceptibility.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Lung CT scan on November 27, 2018. Lung CT taken on day 3 shows patchy consolidation in left inferior lobar
Fig. 2
Fig. 2
Lung CT scan on January 4, 2019. Lung CT taken on day 11 shows patchy consolidation in both lungs
Fig. 3
Fig. 3
Global distribution of Pandoraea spp. Most Pandoraea cases occurred in Europe, America, and Australia, which was consistent with the epidemiology of CF
See this image and copyright information in PMC

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