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Randomized Controlled Trial
. 2019 Oct 17;29(4):577-586.
doi: 10.18865/ed.29.4.577. eCollection 2019 Fall.

Stress Reduction in the Prevention of Left Ventricular Hypertrophy: A Randomized Controlled Trial of Transcendental Meditation and Health Education in Hypertensive African Americans

Robert H Schneider  1 , Hector F Myers  2 , Komal Marwaha  1 , Maxwell A Rainforth  1 , John W Salerno  1 , Sanford I Nidich  1 , Carolyn Gaylord-King  1 , Charles N Alexander  1 , Keith C Norris  3
Affiliations
Randomized Controlled Trial

Stress Reduction in the Prevention of Left Ventricular Hypertrophy: A Randomized Controlled Trial of Transcendental Meditation and Health Education in Hypertensive African Americans

Robert H Schneider et al. Ethn Dis. .

Abstract

Background: African Americans have disproportionately high rates of cardiovascular disease (CVD). Left ventricular hypertrophy (LVH) is an independent risk factor for CVD and may contribute to this disparity. Psychological stress contributes to LVH in African Americans and other populations.

Objective: This study evaluated the effects of stress reduction with the Transcendental Meditation (TM) technique on preventing LVH in African American adults with hypertension.

Setting: Martin Luther King Hospital - Charles R. Drew University of Medicine and Science, Los Angeles, CA.

Method: In this trial, 85 African American adults (average 52.8 years) were randomly assigned to either TM program or health education (HE) control group and completed posttesting. Participants were tested at baseline and after six months for left ventricular mass index (LVMI) by M-mode echocardiography, blood pressure, psychosocial stress and behavioral factors. Change in outcomes was analyzed between groups by ANCOVA and within groups by paired t-test.

Results: The TM group had significantly lower LVMI compared with the HE group (-7.55gm/m2, 95% CI -14.78 to -.34 gm/m2, P=.040). Both interventions showed significant within group reductions in BP, (SBP/DBP changes for TM: -5/ -3 mm Hg, and for HE: -7/-6 mm Hg, P=.028 to <.001) although between group changes were not significant. In addition, both groups showed significant reductions in anger (P=.002 to .001). There were no other changes in lifestyle factors.

Conclusions: These findings indicate that stress reduction with TM was effective in preventing LVMI progression and thus may prevent LVH and associated CVD in high-risk African American patients.

Keywords: Cardiovascular Disease; Health Disparity; Left Ventricular Hypertrophy; Left Ventricular Mass Index; Stress Reduction; Transcendental Meditation.

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Conflict of interest statement

Competing Interests: None declared.

Figures

Figure 1.
Figure 1.. Flow of participants from randomization to analysis
a. estimated.
Figure 2.
Figure 2.. Change in left ventricle mass index (±standard error of mean) between the groups after six-month intervention
TM; Transcendental Meditation, HE; health education, LVMI; left ventricle mass index. a. significant P.
See this image and copyright information in PMC

References

    1. Carnethon MR, Pu J, Howard G, et al. ; American Heart Association Council on Epidemiology and Prevention; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Functional Genomics and Translational Biology; and Stroke Council . Cardiovascular Health in African Americans: A Scientific Statement From the American Heart Association. Circulation. 2017;136(21):e393-e423. 10.1161/CIR.0000000000000534 - DOI - PubMed
    1. Bauml MA, Underwood DA. Left ventricular hypertrophy: an overlooked cardiovascular risk factor. Cleve Clin J Med. 2010;77(6):381-387. 10.3949/ccjm.77a.09158 - DOI - PubMed
    1. Koren MJ, Mensah GA, Blake J, Laragh JH, Devereux RB. Comparison of left ventricular mass and geometry in black and white patients with essential hypertension. Am J Hypertens. 1993;6(10):815-823. 10.1093/ajh/6.10.81510.1093/ajh/6.10.815 - DOI - DOI - PubMed
    1. Schnall PL, Pieper C, Schwartz JE, et al. . The relationship between ‘job strain,’ workplace diastolic blood pressure, and left ventricular mass index. Results of a case-control study. JAMA. 1990;263(14):1929-1935. 10.1001/jama.1990.03440140055031 - DOI - PubMed
    1. Taylor TR, Kamarck TW, Dianzumba S. Cardiovascular reactivity and left ventricular mass: an integrative review. Ann Behav Med. 2003;26(3):182-193. 10.1207/S15324796ABM2603_03 - DOI - PubMed

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