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Case Reports
. 2019 Sep 18:2019:4307281.
doi: 10.1155/2019/4307281. eCollection 2019.

Case Reports on Metaplastic Squamous Cell Carcinoma of the Breast and Treatment Dilemma

Anita Pandey  1   2   3 , Kishor Joshi  1   2   3 , Harry Moussouris  1   2   3 , Gardith Joseph  1   2   3
Affiliations
Case Reports

Case Reports on Metaplastic Squamous Cell Carcinoma of the Breast and Treatment Dilemma

Anita Pandey et al. Case Rep Oncol Med. .

Abstract

Metaplastic squamous cell carcinoma of the breast is a very rare form of breast cancer that consists of both glandular and nonglandular components mixed with epithelial and mesenchymal tissues. Worldwide, the incidence of this tumor is between 0.1 and 2%. Because of the rarity of this tumor and heterogeneous behavior of the tumor cells, it is difficult to establish the standard therapeutic approach. We report 2 cases of metaplastic squamous cell carcinoma of the breast in young patients with different responses to treatment strategies. The first case is a premenopausal female with metaplastic squamous cell carcinoma treated with surgery, chemotherapy, and radiotherapy, and the second case is perimenopausal metaplastic squamous cell carcinoma with sarcomatoid subtype and osteoid matrix production which progressed on chemotherapy and was treated with surgery and radiation.

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Conflict of interest statement

The authors declare no conflict of interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
Sonogram of the left breast showing hypoechoic lesion.
Figure 2
Figure 2
Mammogram of the left breast.
Figure 3
Figure 3
MRI left breast.
Figure 4
Figure 4
High-grade features with cell atypia.
Figure 5
Figure 5
Cell atypia with necrosis.
Figure 6
Figure 6
Left breast sonogram showing a cystic mass.
Figure 7
Figure 7
Left breast mammogram.
Figure 8
Figure 8
MRI left breast.
Figure 9
Figure 9
Cells with sarcomatoid differentiation.
Figure 10
Figure 10
Lymph node biopsy—lymphocyte aggregates and adjacent tumor cells.
See this image and copyright information in PMC

References

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