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Review

Nisoldipine

No authors listed
In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012.
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Review

Nisoldipine

No authors listed.
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Excerpt

Nisoldipine is a second generation calcium channel blocker and commonly used antihypertensive agent. Nisoldipine therapy is associated with a low rate of serum enzyme elevations, but has not been specifically linked to instances of clinical apparent acute liver injury.

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References

    1. Zimmerman HJ. Calcium channel blockers. Drugs used in cardiovascular disease. In, Zimmerman HJ. Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. 2nd ed. Philadelphia: Lippincott, 1999, pp. 646-7.(Expert review of hepatotoxicity published in 1999; among calcium channel blockers, diltiazem, nifedipine, bepridil and verapamil have been incriminated in instances of hepatic injury; nisoldipine is not mentioned).
    1. De Marzio DH, Navarro VJ. Calcium channel blockers. Hepatotoxicity of cardiovascular and antidiabetic drugs. In, Kaplowitz N, DeLeve LD, eds. Drug-induced liver disease. 3rd ed. Amsterdam: Elsevier, 2013, pp. 524.(Review of hepatotoxicity of calcium channel blockers mentions that diliazem, nifedipine and verapamil have been implicated in causing cholestatic liver injury; nisoldipine is not mentioned).
    1. Michel T, Hoffman BB. Calcium channel antagonists. Treatment of myocardial ischemia. In, Brunton LL, Chabner BA, Knollman BC, eds. Goodman & Gilman’s the pharmacological basis of therapeutics. 12th ed. New York: McGraw-Hill, 2011, pp. 755-60.(Textbook of pharmacology and therapeutics).
    1. Knorr A. The pharmacology of nisoldipine. Cardiovasc Drugs Ther 1987; 1: 393-402. (Review of pharmacology of nisoldipine). - PubMed
    1. Friedel HA, Sorkin EM. Nisoldipine. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of angina pectoris, hypertension and related cardiovascular disorders. Drugs 1988; 36: 682-731. (Review of pharmacology, efficacy and safety of nisoldipine;side effects are largely due to the vasodilating activty of nisoldipine, and in clinical trials no "clinically important" biochemical laboratory changes occurred). - PubMed

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