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. 2019 Oct 17;94(4):458-460.
doi: 10.1590/abd1806-4841.20198349. eCollection 2019.

BRAFV600E and KIT immunoexpression in early-stage melanoma

Andressa Germano  1 , Leonardo Cardili  2 , Fernando Cintra Lopes Carapeto  1 , Gilles Landman  2
Affiliations

BRAFV600E and KIT immunoexpression in early-stage melanoma

Andressa Germano et al. An Bras Dermatol. .

Abstract

Melanoma is widely known as the most lethal skin cancer. Specific tumor-related mortality can be significantly reduced if diagnosis and treatment are properly performed during initial phases of the disease. The current search for biomarkers in early-stage melanomas is a high-priority challenge for physicians and researchers. We aimed to assess the immunoexpression of BRAFV600E and KIT in a case series consisting of 44 early-stage melanomas. Formalin-fixed paraffin-embedded samples were systematically evaluated using a semi-quantitative method based on scores of percentage and intensity for immunostained tumor cells. We observed significant concordance between BRAFV600E and KIT immunoexpression in thin invasive melanomas. Our findings corroborate previous evidence showing abnormal expression of proteins associated with MAPK intracellular signaling pathway in early-stage melanomas.

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Conflict of interest statement

Conflict of interest: None.

Figures

Figure 1
Figure 1
Melanoma in situ, KIT-positive. Atypical melanocytes dis played in a lentiginous pattern showing immunolabeling for KIT
Figure 2
Figure 2
Melanoma in situ, VE1-positive. The lentiginous component of this VE1-positive lesion extends into the distal segment of an ec crine duct
See this image and copyright information in PMC

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