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Editorial
. 2019 Oct 23;11(20):8730-8732.
doi: 10.18632/aging.102341. Epub 2019 Oct 23.

Embrace the fat when getting old

Lorenz Adlung  1 , Ido Amit  1 , Eran Elinav  1   2
Affiliations
Editorial

Embrace the fat when getting old

Lorenz Adlung et al. Aging (Albany NY). .
No abstract available

Keywords: Trem2; adipose; cardiometabolic disease; macrophages; obesity.

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Conflict of interest statement

Conflicts of Interest: E.E. is a paid consultant at DayTwo and BiomX. None of this work is related to, funded or endorsed by, shared or discussed with or licensed to any commercial entity. None of the other authors has any competing interest.

Figures

Figure 1
Figure 1
Lipid-Associated Macrophage (LAM) cells expressing Trem2 surround adipocytes in “crown-like structures” thereby preventing leakage of potentially harmful substances to the periphery with systemic consequences. Aging and/or obesity may eventually lead to a loss of LAM cells and thus bursting of hypertrophic adipocytes. Metabolic derailments could putatively be counteracted by activation of Trem2 or pharmacological inhibition of Trem1.
See this image and copyright information in PMC

References

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