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Case Reports
. 2019 Oct 3;5(10):898-903.
doi: 10.1016/j.jdcr.2019.07.015. eCollection 2019 Oct.

Nonbullous pemphigoid secondary to PD-1 inhibition

Affiliations
Case Reports

Nonbullous pemphigoid secondary to PD-1 inhibition

Sean Singer et al. JAAD Case Rep. .
No abstract available

Keywords: BP, bullous pemphigoid; BP180, anti–bullous pemphigoid 180; BP230, anti–bullous pemphigoid 230; DIF, direct immunofluorescence; ELISA, enzyme-linked immunosorbent assay; ICI, immune checkpoint inhibitor; IIF, indirect immunofluorescence; Ig, immunoglobulin; NBP, nonbullous pemphigoid; PD-1; PD-1, programmed cell death 1; bullous pemphigoid; immune checkpoint inhibitor; immune-related adverse event; nonbullous pemphigoid.

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Figures

Fig 1
Fig 1
A, Clinical presentation of case 1. Erythematous papules coalescing into plaques on the lower portion of the back. B, Histopathology of case 1. Eosinophilic spongiosis with tagging of eosinophils at dermal-epidermal junction.
Fig 2
Fig 2
Other clinical images of nonbullous pemphigoid secondary to programmed cell death 1 inhibitor therapy. A, Pink edematous papules on the trunk in case 2. B, Urticarial plaques with central scale on the lower portion of the back in case 3.

References

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    1. Siegel J., Totonchy M., Damsky W. Bullous disorders associated with anti–PD-1 and anti–PD-L1 therapy: a retrospective analysis evaluating the clinical and histopathologic features, frequency, and impact on cancer therapy. J Am Acad Dermatol. 2018;79(6):1081–1088. - PubMed
    1. Lopez A.T., Khanna T., Antonov N., Audrey-Bayan C., Geskin L. A review of bullous pemphigoid associated with PD-1 and PD-L1 inhibitors. Int J Dermatol. 2018;57(6):664–669. - PubMed

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